Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24398058 | 1.00 | POLB (0.38) | POLBGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL29601380 | 0.95 | POLB (0.37) | POLBGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL24397817 | 0.95 | POLB (0.37) | POLBGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL29601355 | 0.90 | POLB (0.36) | POLBGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL24397912 | 0.90 | POLB (0.36) | POLBGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL26926961 | 0.89 | GAA (0.32) | POLBGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL24803185 | 0.85 | KMT2A (0.39) | POLBGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL30304261 | 0.84 | POLB (0.37) | POLBGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL24802230 | 0.84 | POLB (0.37) | POLBGAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL24802228 | 0.83 | POLB (0.40) | POLBGAARAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4237404-A1 | NOVEL COMPOUNDS | Sitryx Therapeutics Limited (GB) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022090724-A1 | NOVEL COMPOUNDS | SITRYX THERAPEUTICS LIMITED (GB) | 2022-05-05 | — | — | WO | disclosed |