Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 3/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24802230 | 1.00 | POLB (0.37) | POLBGAAHPGDSMN1; SMN2MAPT | |
| SCHEMBL24801649 | 0.89 | POLB (0.36) | POLBGAAHPGDSMN1; SMN2MAPT | |
| SCHEMBL30304260 | 0.89 | POLB (0.36) | POLBGAAHPGDSMN1; SMN2MAPT | |
| SCHEMBL29601380 | 0.88 | POLB (0.37) | POLBGAAHPGDSMN1; SMN2MAPT | |
| SCHEMBL24397817 | 0.88 | POLB (0.37) | POLBGAAHPGDSMN1; SMN2MAPT | |
| SCHEMBL24803185 | 0.87 | KMT2A (0.39) | POLBGAAHPGDSMN1; SMN2MAPT | |
| SCHEMBL24802228 | 0.87 | POLB (0.40) | POLBGAAHPGDSMN1; SMN2MAPT | |
| SCHEMBL24398058 | 0.84 | POLB (0.38) | POLBGAAHPGDSMN1; SMN2MAPT | |
| SCHEMBL24801165 | 0.84 | SLC6A3 (0.40) | MAPTPDE2A | |
| SCHEMBL29600795 | 0.84 | POLB (0.38) | POLBGAAHPGDSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359390-A1 | ACRYLAMIDE DERIVATIVES USEFUL AS ANTI-INFLAMMATORY AGENTS | Sitryx Therapeutics Limited (GB) | 2024-05-01 | — | — | EP | disclosed |
| WO-2022269251-A1 | ACRYLAMIDE DERIVATIVES USEFUL AS ANTI-INFLAMMATORY AGENTS | SITRYX THERAPEUTICS LIMITED (GB) | 2022-12-29 | — | — | WO | disclosed |