Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 18/20 | 0.61 |
| ▸ | EGFR | P00533 | 5/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.61 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2958098 | 0.87 | IGF1R (0.69) | IGF1REGFRERBB2 | |
| SCHEMBL16762566 | 0.86 | IGF1R (0.65) | IGF1REGFRERBB2KDRRET | |
| SCHEMBL2960561 | 0.85 | IGF1R (0.60) | IGF1REGFRERBB2KDRRET | |
| SCHEMBL2965414 | 0.84 | IGF1R (0.72) | IGF1REGFRERBB2 | |
| SCHEMBL2966960 | 0.84 | IGF1R (0.72) | IGF1REGFRERBB2 | |
| SCHEMBL2965412 | 0.84 | IGF1R (0.72) | IGF1REGFRERBB2 | |
| SCHEMBL2960985 | 0.84 | IGF1R (0.68) | IGF1REGFRERBB2 | |
| SCHEMBL2960097 | 0.84 | IGF1R (0.59) | IGF1REGFRERBB2KDRRET | |
| SCHEMBL2953928 | 0.84 | IGF1R (0.70) | IGF1REGFRERBB2 | |
| SCHEMBL2953930 | 0.84 | IGF1R (0.70) | IGF1REGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772231-B2 | Substituted pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors | ABBOTT LABORATORIES (US) | 2010-08-10 | — | — | US | claimed |
| EP-1973917-A2 | PROTEIN KINASE INHIBITORS | Abbott Laboratories (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007079164-A2 | PROTEIN KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2007-07-12 | — | — | WO | disclosed |