Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21484711 | 1.00 | GSK3B (0.56) | GSK3BDRD3HDAC3HDAC4HDAC1 | |
| Bromide SCHEMBL27039939 | 0.98 | GSK3B (0.54) | GSK3BDRD3HDAC3HDAC4HDAC1 | |
| SCHEMBL22065262 | 0.84 | DRD3 (0.47) | GSK3BDRD3HDAC3HDAC4HDAC1 | |
| Bromide SCHEMBL30518647 | 0.83 | P4HTM (0.44) | GSK3BP4HTMALDH1A1CYP1A2POLB | |
| SCHEMBL27039929 | 0.83 | DRD3 (0.46) | GSK3BDRD3HDAC3HDAC4HDAC1 | |
| SCHEMBL27039826 | 0.82 | ACACB (0.43) | GSK3BP4HTMALDH1A1POLBGLA | |
| SCHEMBL31312950 | 0.81 | DRD3 (0.45) | DRD3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL29023495 | 0.80 | P4HTM (0.39) | GSK3BDRD3P4HTMGRIN2BGRIN1 | |
| SCHEMBL287134 | 0.78 | P4HTM (0.60) | DRD3P4HTMALDH1A1HPGDCYP1A2 | |
| SCHEMBL2187078 | 0.78 | DRD3 (0.47) | DRD3P4HTMALDH1A1HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232449-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | Celgene Corporation (US) | 2023-08-30 | — | — | EP | disclosed |
| CN-116547282-A | Heterocyclic compounds and their use for the treatment of helminth infections and diseases | 新基公司 | 2023-08-04 | — | — | CN | disclosed |
| WO-2022087326-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CELGENE CORPORATION (US) | 2022-04-28 | — | — | WO | disclosed |