Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | CCR8 | P51685 | 1/20 | 0.42 |
| ▸ | CTSA | P10619 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8119356 | 1.00 | GSK3B (0.46) | GSK3BUHRF1CCR1CCR5CCR8 | |
| Bromide SCHEMBL6173297 | 0.98 | GSK3B (0.44) | GSK3BUHRF1CCR1CCR5CCR8 | |
| Bromide SCHEMBL29601226 | 0.98 | GSK3B (0.44) | GSK3BUHRF1CCR1CCR5CCR8 | |
| Bromide SCHEMBL27039809 | 0.96 | GSK3B (0.43) | GSK3BUHRF1CCR1CCR5CCR8 | |
| SCHEMBL30885027 | 0.83 | UHRF1 (0.43) | UHRF1CCR1CCR5CCR8CTSA | |
| SCHEMBL2643034 | 0.83 | UHRF1 (0.43) | UHRF1CCR1CCR5CCR8CTSA | |
| SCHEMBL17820448 | 0.83 | UHRF1 (0.43) | UHRF1CCR1CCR5CCR8CTSA | |
| Hydrochloric Acid SCHEMBL6788469 | 0.80 | MEN1 (0.41) | UHRF1CCR1CCR5CCR8CTSA | |
| SCHEMBL15926105 | 0.80 | CTSA (0.43) | UHRF1CCR1CCR5CCR8CTSA | |
| SCHEMBL2067966 | 0.80 | GABRA1 (0.46) | UHRF1CCR1CCR5CCR8CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232449-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | Celgene Corporation (US) | 2023-08-30 | — | — | EP | disclosed |
| CN-116547282-A | Heterocyclic compounds and their use for the treatment of helminth infections and diseases | 新基公司 | 2023-08-04 | — | — | CN | disclosed |
| WO-2022087326-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CELGENE CORPORATION (US) | 2022-04-28 | — | — | WO | disclosed |