Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.75 |
| ▸ | RAB9A | P51151 | 10/20 | 0.75 |
| ▸ | GAA | P10253 | 6/20 | 0.75 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.75 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.75 |
| ▸ | RELA | Q04206 | 4/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.68 |
| ▸ | MAPT | P10636 | 6/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.68 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.68 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.68 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.68 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 7/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24358063 | 1.00 | NPC1 (0.75) | NPC1RAB9AGAANFKB1NFKB2 | |
| SCHEMBL24358267 | 0.89 | NPC1 (0.65) | NPC1RAB9AGAANFKB1NFKB2 | |
| SCHEMBL30745719 | 0.89 | NPC1 (0.65) | NPC1RAB9AGAANFKB1NFKB2 | |
| SCHEMBL24358014 | 0.88 | NPC1 (0.64) | NPC1RAB9AGAANFKB1NFKB2 | |
| SCHEMBL30518659 | 0.88 | NPC1 (0.64) | NPC1RAB9AGAANFKB1NFKB2 | |
| SCHEMBL24358031 | 0.86 | NPC1 (0.61) | NPC1RAB9AGAANFKB1NFKB2 | |
| SCHEMBL30745763 | 0.86 | NPC1 (0.61) | NPC1RAB9AGAANFKB1NFKB2 | |
| SCHEMBL3407963 | 0.86 | RAB9A (1.00) | NPC1RAB9AGAANFKB1NFKB2 | |
| SCHEMBL29858646 | 0.86 | RAB9A (1.00) | NPC1RAB9AGAANFKB1NFKB2 | |
| SCHEMBL24358076 | 0.85 | NPC1 (0.60) | NPC1RAB9AGAANFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025891-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CELGENE CORPORATION | 2024-01-25 | — | — | US | disclosed |
| EP-4232449-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | Celgene Corporation (US) | 2023-08-30 | — | — | EP | disclosed |
| CN-116547282-A | Heterocyclic compounds and their use for the treatment of helminth infections and diseases | 新基公司 | 2023-08-04 | — | — | CN | disclosed |
| WO-2022087326-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CELGENE CORPORATION (US) | 2022-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240025891-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CYP8B1, PAH, INHA | NPC1 2626/4885RAB9A 1887/4885GAA 1465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.