Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Triethylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.32 |
| ▸ | TET3 | O43151 | 1/20 | 0.32 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PGK1 | P00558 | 1/20 | 0.30 |
| ▸ | PGK2 | P07205 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL2952394 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1KMT2AOR51E2TSHR | |
| Malic Acid SCHEMBL2959731 | 0.95 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1KMT2AOR51E2TSHR | |
| Triethylene Glycol SCHEMBL30580745 | 0.88 | SMN1; SMN2 (0.62) | SMN1; SMN2MEN1KMT2AOR51E2TSHR | |
| Triethylene Glycol SCHEMBL28065453 | 0.88 | SMN1; SMN2 (0.62) | SMN1; SMN2MEN1KMT2AOR51E2TSHR | |
| Malic Acid SCHEMBL2955610 | 0.88 | SMN1; SMN2 (0.46) | SMN1; SMN2OR51E2TET2TET3TET1 | |
| Malic Acid SCHEMBL27714812 | 0.86 | SMN1; SMN2 (0.65) | SMN1; SMN2MEN1KMT2AOR51E2TSHR | |
| Triethylene Glycol SCHEMBL2960132 | 0.84 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1KMT2AOR51E2TSHR | |
| Malic Acid SCHEMBL2961462 | 0.84 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1KMT2AOR51E2TSHR | |
| Malic Acid SCHEMBL2963355 | 0.83 | SMN1; SMN2 (0.52) | SMN1; SMN2MEN1KMT2AOR51E2TSHR | |
| Diethylene Glycol Monoethyl Ether SCHEMBL9054038 | 0.83 | SMN1; SMN2 (0.52) | SMN1; SMN2MEN1KMT2AOR51E2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7766978-B2 | Acidic hair dyeing method | KOKYU ALCOHOL KOGYO CO., LTD. (JP) | 2010-08-03 | — | — | US | disclosed |
| US-20090100609-A1 | ACIDIC HAIR DYE COMPOSITION | KOKYU ALCOHOL KOGYO CO., LTD. (JP) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090100609-A1 | ACIDIC HAIR DYE COMPOSITION | H1-0, MRM1, H1-4 | SMN1; SMN2 3802/4885MEN1 157/4885KMT2A 2163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.