Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27039749 | 1.00 | KMT2A (0.40) | KMT2AMAPK1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL24775612 | 0.81 | MAPK1 (0.64) | KMT2AMAPK1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2109944 | 0.78 | MAPK1 (0.50) | KMT2AMAPK1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2108606 | 0.78 | P4HTM (0.56) | KMT2AMAPK1ALDH1A1L3MBTL1MAPT | |
| SCHEMBL25196397 | 0.77 | PARP10 (0.42) | KMT2AMAPK1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL1004608 | 0.75 | MAPK1 (0.64) | MAPK1SMN1; SMN2HPGDL3MBTL1MAPT | |
| SCHEMBL12663306 | 0.75 | KDM4E (0.42) | ALDH1A1HPGDMAPTKDM4ERAB9A | |
| SCHEMBL22531099 | 0.74 | RAB9A (0.43) | KMT2AMAPK1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL22531098 | 0.74 | RAB9A (0.43) | KMT2AMAPK1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL29388906 | 0.74 | RAB9A (0.43) | KMT2AMAPK1SMN1; SMN2L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232449-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | Celgene Corporation (US) | 2023-08-30 | — | — | EP | disclosed |
| CN-116547282-A | Heterocyclic compounds and their use for the treatment of helminth infections and diseases | 新基公司 | 2023-08-04 | — | — | CN | disclosed |
| WO-2022087326-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CELGENE CORPORATION (US) | 2022-04-28 | — | — | WO | disclosed |