Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 4/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14263026 | 1.00 | BRD4 (0.50) | BRD4MAPTMAPK1CYP1A2CYP3A4 | |
| SCHEMBL19691717 | 0.86 | BRD4 (0.49) | BRD4MAPTMAPK1CYP1A2CYP3A4 | |
| SCHEMBL2705086 | 0.85 | BRD4 (0.48) | BRD4MAPTMAPK1CYP1A2CYP3A4 | |
| SCHEMBL509093 | 0.85 | BRD4 (0.48) | BRD4MAPTMAPK1CYP1A2CYP3A4 | |
| SCHEMBL14697792 | 0.85 | BRD4 (0.48) | BRD4MAPTMAPK1CYP2C19LMNA | |
| SCHEMBL18198238 | 0.81 | BRD4 (0.42) | BRD4MAPTMAPK1CYP1A2CYP3A4 | |
| SCHEMBL29601361 | 0.81 | ALDH1A1 (0.51) | BRD4MAPTMAPK1CYP1A2CYP3A4 | |
| SCHEMBL108857 | 0.80 | BRD4 (0.63) | BRD4MAPTMAPK1CYP1A2CYP3A4 | |
| SCHEMBL5312789 | 0.80 | BRD4 (0.43) | BRD4MAPTMAPK1CYP1A2CYP3A4 | |
| SCHEMBL14697735 | 0.79 | BRD4 (0.43) | BRD4MAPTMAPK1LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232449-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | Celgene Corporation (US) | 2023-08-30 | — | — | EP | disclosed |
| CN-116547282-A | Heterocyclic compounds and their use for the treatment of helminth infections and diseases | 新基公司 | 2023-08-04 | — | — | CN | disclosed |
| WO-2022087326-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CELGENE CORPORATION (US) | 2022-04-28 | — | — | WO | disclosed |