Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Exatecan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 known ✓ | P11387 | 19/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Exatecan SCHEMBL7255477 | 1.00 | TOP1 (0.60) | TOP1MEN1KMT2A | |
| Exatecan SCHEMBL29351332 | 1.00 | TOP1 (0.60) | TOP1MEN1KMT2A | |
| Exatecan SCHEMBL31615015 | 1.00 | TOP1 (0.60) | TOP1MEN1KMT2A | |
| Exatecan SCHEMBL23471938 | 1.00 | TOP1 (0.60) | TOP1MEN1KMT2A | |
| Exatecan SCHEMBL2512959 | 1.00 | TOP1 (0.60) | TOP1MEN1KMT2A | |
| Exatecan SCHEMBL25349032 | 1.00 | TOP1 (0.60) | TOP1MEN1KMT2A | |
| Exatecan SCHEMBL7249645 | 1.00 | TOP1 (0.60) | TOP1MEN1KMT2A | |
| Exatecan SCHEMBL26320 | 1.00 | TOP1 (0.60) | TOP1MEN1KMT2A | |
| Exatecan SCHEMBL7163616 | 0.99 | TOP1 (0.59) | TOP1MEN1KMT2A | |
| Exatecan SCHEMBL6047672 | 0.99 | TOP1 (0.59) | TOP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024008102-A1 | LINKER FOR CONJUGATION | WUXI XDC (SHANGHAI) CO., LTD. (CN) | 2024-01-11 | — | — | WO | disclosed |
| EP-3997093-A1 | PEPTIDE CONJUGATES OF CYTOTOXINS AS THERAPEUTICS | Cybrexa 2, Inc. (US) | 2022-05-18 | — | — | EP | disclosed |