Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 10/20 | 0.47 |
| ▸ | KDM4D | Q6B0I6 | 6/20 | 0.47 |
| ▸ | KDM6B | O15054 | 5/20 | 0.47 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.44 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | KDM4A | O75164 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18422044 | 0.83 | IRAK4 (0.50) | IRAK4TDP1SIRT3KDM4CKDM4D | |
| SCHEMBL29892972 | 0.81 | KDM4C (0.52) | IRAK4TDP1SIRT3KDM4CKDM4D | |
| SCHEMBL4934772 | 0.81 | IRAK4 (0.49) | IRAK4TDP1SIRT3KDM4CKDM4D | |
| SCHEMBL17711000 | 0.80 | KDM4C (0.51) | IRAK4TDP1SIRT3KDM4CKDM4D | |
| SCHEMBL18421265 | 0.80 | KDM4C (0.51) | IRAK4TDP1SIRT3KDM4CKDM4D | |
| SCHEMBL2015798 | 0.80 | KDM4D (0.63) | IRAK4TDP1SIRT3KDM4CKDM4D | |
| SCHEMBL18421178 | 0.79 | TSHR (0.49) | IRAK4TDP1SIRT3KDM4CKDM4D | |
| SCHEMBL17723987 | 0.79 | KDM4C (0.71) | IRAK4TDP1SIRT3KDM4CKDM4D | |
| SCHEMBL16703189 | 0.78 | GSK3B (0.53) | IRAK4SIRT2MAPTGLAHTT | |
| SCHEMBL20339713 | 0.78 | KDM4C (0.57) | IRAK4TDP1SIRT3KDM4CKDM4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232449-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | Celgene Corporation (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022087326-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CELGENE CORPORATION (US) | 2022-04-28 | — | — | WO | disclosed |