Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 3/20 | 0.49 |
| ▸ | KDM5C | P41229 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | KDM6B | O15054 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.49 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.45 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.45 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.45 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.45 |
| ▸ | KDM4B | O94953 | 2/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL27039758 | 1.00 | KDM4A (0.49) | KDM4AKDM5CKDM4EKDM6BKDM4C | |
| SCHEMBL29078755 | 0.83 | KCNN1 (0.42) | KDM4AKDM5CKDM4ESLC2A1ALDH1A1 | |
| SCHEMBL24358148 | 0.83 | KCNN1 (0.64) | KDM4ESLC2A1GRM4KCNN1KCNN2 | |
| SCHEMBL24358064 | 0.82 | GABRA5 (0.45) | SLC2A1ALDH1A1LMNAMAPK10RXFP1 | |
| SCHEMBL29601482 | 0.82 | GABRA5 (0.45) | SLC2A1ALDH1A1LMNAMAPK10RXFP1 | |
| SCHEMBL30745793 | 0.81 | GRM4 (0.63) | KDM4ESLC2A1ALDH1A1LMNAMAPK10 | |
| SCHEMBL5174932 | 0.81 | GRM4 (0.63) | KDM4ESLC2A1ALDH1A1LMNAMAPK10 | |
| Bromide SCHEMBL29601604 | 0.79 | CSNK2A2 (0.71) | KDM4AKDM5CKDM4EKDM6BKDM4C | |
| SCHEMBL24358103 | 0.78 | GRM4 (0.47) | KDM4ESLC2A1GRM4KCNN1KCNN2 | |
| SCHEMBL30745728 | 0.78 | GRM4 (0.47) | KDM4ESLC2A1GRM4KCNN1KCNN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232449-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | Celgene Corporation (US) | 2023-08-30 | — | — | EP | disclosed |
| CN-116547282-A | Heterocyclic compounds and their use for the treatment of helminth infections and diseases | 新基公司 | 2023-08-04 | — | — | CN | disclosed |
| WO-2022087326-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CELGENE CORPORATION (US) | 2022-04-28 | — | — | WO | disclosed |