Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 6/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14054179 | 1.00 | OPRK1 (0.46) | OPRK1TSHRNPSR1POLBHSD17B10 | |
| SCHEMBL18765932 | 0.83 | OPRK1 (0.47) | OPRK1 | |
| SCHEMBL5864153 | 0.81 | OPRK1 (0.50) | OPRK1TSHRNPSR1POLBHSD17B10 | |
| SCHEMBL15527494 | 0.81 | OPRK1 (0.50) | OPRK1TSHRNPSR1POLBHSD17B10 | |
| SCHEMBL10668140 | 0.80 | OPRK1 (0.49) | OPRK1TSHRNPSR1POLBHSD17B10 | |
| SCHEMBL15540688 | 0.79 | KDM4E (0.44) | TSHRNPSR1POLBHSD17B10MEN1 | |
| SCHEMBL1887152 | 0.79 | CHEK2 (0.56) | OPRK1TSHRNPSR1POLBHSD17B10 | |
| SCHEMBL15527865 | 0.79 | OPRK1 (0.48) | OPRK1TSHRNPSR1POLBHSD17B10 | |
| SCHEMBL20472328 | 0.79 | OPRK1 (0.48) | OPRK1TSHRNPSR1POLBHSD17B10 | |
| SCHEMBL18398582 | 0.79 | OPRK1 (0.48) | OPRK1TSHRNPSR1POLBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983074-A1 | PYRIDINE CARBAMATES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2022-04-20 | — | — | EP | disclosed |