Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 6/20 | 0.62 |
| ▸ | JAK2 | O60674 | 5/20 | 0.62 |
| ▸ | SRC | P12931 | 5/20 | 0.62 |
| ▸ | KDR | P35968 | 5/20 | 0.62 |
| ▸ | RET | P07949 | 5/20 | 0.62 |
| ▸ | PLK4 | O00444 | 3/20 | 0.62 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.62 |
| ▸ | INSR | P06213 | 3/20 | 0.62 |
| ▸ | LCK | P06239 | 3/20 | 0.62 |
| ▸ | FYN | P06241 | 3/20 | 0.62 |
| ▸ | CDK1 | P06493 | 3/20 | 0.62 |
| ▸ | PRKACA | P17612 | 3/20 | 0.62 |
| ▸ | MARK3 | P27448 | 3/20 | 0.62 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.62 |
| ▸ | FLT4 | P35916 | 3/20 | 0.62 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.62 |
| ▸ | GSK3B | P49841 | 3/20 | 0.62 |
| ▸ | BLK | P51451 | 3/20 | 0.62 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.62 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6107749 | 1.00 | AURKB (0.62) | AURKBJAK2SRCKDRRET | |
| SCHEMBL2960411 | 1.00 | AURKB (0.62) | AURKBJAK2SRCKDRRET | |
| SCHEMBL20533262 | 0.86 | SRC (0.70) | AURKBJAK2SRCKDRRET | |
| SCHEMBL29999054 | 0.83 | JAK2 (0.86) | AURKBJAK2SRCKDRRET | |
| SCHEMBL24096480 | 0.83 | JAK2 (0.86) | AURKBJAK2SRCKDRRET | |
| SCHEMBL14268416 | 0.83 | RET (0.60) | AURKBJAK2SRCKDRRET | |
| SCHEMBL4818639 | 0.82 | SRC (0.59) | AURKBJAK2SRCKDRRET | |
| SCHEMBL18539078 | 0.80 | SRC (0.76) | AURKBJAK2SRCKDRRET | |
| SCHEMBL2960099 | 0.79 | SRC (0.55) | AURKBJAK2SRCKDRRET | |
| SCHEMBL3817960 | 0.79 | SRC (0.67) | AURKBJAK2SRCKDRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973917-B1 | PROTEIN KINASE INHIBITORS | ABBVIE INC (US) | 2015-06-10 | — | — | EP | disclosed |
| US-7772231-B2 | Substituted pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors | ABBOTT LABORATORIES (US) | 2010-08-10 | — | — | US | disclosed |
| US-20070203143-A1 | PROTEIN KINASE INHIBITORS | ABBVIE INC. | 2007-08-30 | — | — | US | disclosed |
| US-20060025383-A1 | Aminobenzoxazoles as therapeutic agents | ABBOTT LABORATORIES | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025383-A1 | Aminobenzoxazoles as therapeutic agents | ABL1, MAP3K19, MAP3K20 | AURKB 24/4885JAK2 119/4885SRC 116/4885 |
| US-20070203143-A1 | PROTEIN KINASE INHIBITORS | PACSIN2, MAP3K20, PHKG1 | AURKB 275/4885JAK2 322/4885SRC 106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.