SCHEMBL29604388

SCHEMBL29604388

O=Cc1cc(-c2ccc(F)c(OC(F)F)c2)cnc1F

nearest known ligand 0.46

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRIN1 Q05586 20/20 0.46
GRIN2B Q13224 20/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22770894 1.00 GRIN1 (0.46) GRIN1GRIN2B
SCHEMBL22770858 0.76 GRIN1 (0.48) GRIN1GRIN2B
SCHEMBL22770996 0.76 GRIN1 (0.51) GRIN1GRIN2B
SCHEMBL29869321 0.76 GRIN2B (0.49) GRIN1GRIN2B
SCHEMBL22775262 0.72 GRIN2B (0.46) GRIN1GRIN2B
SCHEMBL22775638 0.71 GRIN1 (0.53) GRIN1GRIN2B
SCHEMBL22787203 0.70 GRIN1 (0.50) GRIN1GRIN2B
SCHEMBL22771420 0.70 GRIN2B (0.55) GRIN1GRIN2B
SCHEMBL22770851 0.70 GRIN1 (0.50) GRIN1GRIN2B
SCHEMBL29603662 0.69 GRIN1 (0.44) GRIN1GRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3983074-A1 PYRIDINE CARBAMATES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS Janssen Pharmaceutica NV (BE) 2022-04-20 EP disclosed