Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.33 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | UBE2N | P61088 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | BCR | P11274 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29605034 | 0.92 | L3MBTL1 (0.44) | L3MBTL1CA1CA2HTTPOLB | |
| SCHEMBL29604944 | 0.85 | L3MBTL1 (0.42) | L3MBTL1CA1CA2HTTPOLB | |
| SCHEMBL29606663 | 0.83 | L3MBTL1 (0.37) | L3MBTL1CA1CA2HTTPOLB | |
| SCHEMBL29604850 | 0.83 | L3MBTL1 (0.37) | L3MBTL1CA1CA2HTTPOLB | |
| SCHEMBL29604888 | 0.80 | CA1 (0.47) | L3MBTL1CA1CA2HTTPOLB | |
| SCHEMBL26969501 | 0.80 | L3MBTL1 (0.41) | L3MBTL1CA1CA2HTTPOLB | |
| SCHEMBL29605582 | 0.80 | L3MBTL1 (0.41) | L3MBTL1CA1CA2HTTPOLB | |
| SCHEMBL29606068 | 0.77 | L3MBTL1 (0.37) | L3MBTL1CA1CA2HTTPOLB | |
| SCHEMBL29604811 | 0.77 | L3MBTL1 (0.38) | L3MBTL1CA1CA2HTTPOLB | |
| SCHEMBL26969488 | 0.77 | L3MBTL1 (0.40) | L3MBTL1CA1CA2HTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4244224-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | JANSSEN Pharmaceutica NV (BE) | 2023-09-20 | — | — | EP | disclosed |
| WO-2022104348-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2022-05-19 | — | — | WO | disclosed |