Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 10/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FER | P16591 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | FRK | P42685 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26969382 | 0.87 | MAP3K14 (0.40) | MAP3K14SMN1; SMN2RAB9ANPC1OPRM1 | |
| SCHEMBL29604716 | 0.87 | MAP3K14 (0.40) | MAP3K14SMN1; SMN2RAB9ANPC1OPRM1 | |
| SCHEMBL29605779 | 0.87 | MAP3K14 (0.40) | MAP3K14SMN1; SMN2RAB9ANPC1OPRM1 | |
| SCHEMBL29605217 | 0.81 | MAP3K14 (0.50) | MAP3K14SMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL29604666 | 0.78 | MAP3K14 (0.48) | MAP3K14SMN1; SMN2RAB9APKD1ALDH1A1 | |
| SCHEMBL29604896 | 0.71 | MAP3K14 (0.41) | MAP3K14IRAK4SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL26643948 | 0.71 | MAP3K14 (0.40) | MAP3K14ABL1PKD1 | |
| SCHEMBL26643943 | 0.71 | MAP3K14 (0.40) | MAP3K14ABL1PKD1 | |
| SCHEMBL26643945 | 0.70 | MAP3K14 (0.40) | MAP3K14 | |
| SCHEMBL26643951 | 0.70 | MAP3K14 (0.40) | MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4244224-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | JANSSEN Pharmaceutica NV (BE) | 2023-09-20 | — | — | EP | disclosed |
| WO-2022104348-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2022-05-19 | — | — | WO | disclosed |