Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.39 |
| ▸ | CDK2 | P24941 | 4/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.39 |
| ▸ | CLK2 | P49760 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | PRKCG | P05129 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | FES | P07332 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14678434 | 1.00 | AXL (0.47) | AXLDYRK1ACDK2CLK4CLK2 | |
| SCHEMBL1666074 | 0.77 | JAK2 (0.54) | AXLDYRK1ACDK2CLK4CLK2 | |
| SCHEMBL91446 | 0.77 | AXL (0.47) | AXLDYRK1ACDK2CLK4CLK2 | |
| SCHEMBL21893812 | 0.77 | GSK3B (0.56) | DYRK1ACDK2CLK4CLK2ROCK2 | |
| SCHEMBL1880862 | 0.77 | BRD4 (0.47) | AXLDYRK1ACDK2CLK4CLK2 | |
| SCHEMBL29928376 | 0.77 | JAK2 (0.54) | AXLDYRK1ACDK2CLK4CLK2 | |
| SCHEMBL14041214 | 0.77 | MET (0.43) | AXLITKGSK3BGSK3ABRAF | |
| SCHEMBL14685266 | 0.77 | CLK1 (0.39) | AXLDYRK1ACDK2CLK4CLK2 | |
| SCHEMBL14678114 | 0.77 | AXL (0.43) | AXLDYRK1ACDK2CLK4CLK2 | |
| Hydrochloric Acid SCHEMBL21988122 | 0.76 | GSK3B (0.54) | DYRK1ACDK2CLK4CLK2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4447954-A1 | HETEROCYCLIC COMPOUNDS AS 5HT2A BIASED AGONISTS | Icahn School of Medicine at Mount Sinai (US) | 2024-10-23 | — | — | EP | disclosed |
| CN-112638477-B | Pyrrolo [2,3-B ] pyridine derivatives as inhibitors of influenza virus replication | 共晶制药公司 | 2024-01-26 | — | — | CN | disclosed |
| EP-4244224-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | JANSSEN Pharmaceutica NV (BE) | 2023-09-20 | — | — | EP | disclosed |
| WO-2023114472-A1 | HETEROCYCLIC COMPOUNDS AS 5HT2A BIASED AGONISTS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-06-22 | — | — | WO | disclosed |
| CN-108727369-B | Influenza virus replication inhibitors and uses thereof | 广东东阳光药业有限公司 | 2023-06-09 | — | — | CN | disclosed |
| CN-110117285-B | Inhibitors of influenza virus replication and uses thereof | 广东东阳光药业有限公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-110637022-B | Pyrrolopyrimidine derivatives as inhibitors of influenza virus replication | 共晶制药公司 | 2022-09-16 | — | — | CN | disclosed |
| WO-2022104348-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2022-05-19 | — | — | WO | disclosed |