SCHEMBL296057

SCHEMBL296057

C1=CC2CC1CC2[SiH2]C(Oc1ccccc1)Oc1ccccc1

nearest known ligand 0.33

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.33
TSHR P16473 1/20 0.33
KCNH2 Q12809 2/20 0.31
LMNA P02545 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
HIF1A Q16665 1/20 0.31
CHRM2 P08172 1/20 0.31
CHRM4 P08173 1/20 0.31
CHRM1 P11229 1/20 0.31
CHRM3 P20309 1/20 0.31
PTGS2 P35354 1/20 0.31
HRH1 P35367 1/20 0.31
HRH3 Q9Y5N1 1/20 0.31
SLC6A2 P23975 1/20 0.30
SLC6A4 P31645 1/20 0.30
SLC6A3 Q01959 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6750631 0.76 KDM4E (0.35) KDM4ETSHRKCNH2LMNACYP3A4
SCHEMBL6063122 0.73 ALDH1A1 (0.31)
SCHEMBL6062891 0.69 KDM4E (0.33) KDM4E
SCHEMBL6697324 0.67 KDM4E (0.36) KDM4ETSHRKCNH2LMNACYP3A4
SCHEMBL6063352 0.66 KDM4E (0.31) KDM4ELMNA
SCHEMBL6902905 0.66 KDM4E (0.31) KDM4ELMNA
SCHEMBL11527107 0.66 KDM4E (0.39) KDM4ETSHRLMNACYP3A4CYP2D6
SCHEMBL3197535 0.65 ALDH1A1 (0.44) KDM4ETSHRLMNA
SCHEMBL6698884 0.65 KDM4E (0.35) KDM4ETSHRKCNH2LMNACYP3A4
SCHEMBL6693466 0.62 KDM4E (0.35) KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1223195-B1 Thermoplastic resin composition and shaped articles thereof JSR CORP (JP) 2012-03-14 EP disclosed
EP-1364975-B1 PROCESSES FOR PRODUCING CYCLOOLEFIN ADDITION POLYMER JSR CORP (JP) 2008-04-30 EP disclosed
US-20070112158-A1 Novel (co)polymer, process for producing the same, and process for producing carboxylated (co)polymer JSR CORPORATION (JP) 2007-05-17 US disclosed
EP-1686139-A1 NOVEL (CO)POLYMER, PROCESS FOR PRODUCING THE SAME, AND PROCESS FOR PRODUCING CARBOXYLATED (CO)POLYMER JSR Corporation (JP) 2006-08-02 EP disclosed
US-6911507-B2 Processes for producing cycloolefin addition polymer JSR CORPORATION (JP) 2005-06-28 US disclosed
US-20040063873-A1 Processes for producing cycloolefin addition polymer JSR CORPORATION (JP) 2004-04-01 US disclosed
EP-1364975-A1 PROCESSES FOR PRODUCING CYCLOOLEFIN ADDITION POLYMER JSR Corporation (JP) 2003-11-26 EP disclosed
US-6562908-B2 Blend of rubber reinforced thermoplastic resins, acrylic resins and thermoplastic norbornene resins; heat resistance, strength, processability, and laser marking properties JSR CORPORATION (JP) 2003-05-13 US disclosed
US-20020128392-A1 Thermoplastic resin composition and shaped articles thereof JSR CORPORATION (JP) 2002-09-12 US disclosed
EP-1223195-A2 Thermoplastic resin composition and shaped articles thereof JSR Corporation (JP) 2002-07-17 EP disclosed