Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 4/20 | 0.76 |
| ▸ | TERT | O14746 | 5/20 | 0.57 |
| ▸ | CYCS | P99999 | 3/20 | 0.54 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL245937 | 0.98 | TOP1 (0.78) | TOP1TERTCYCSENPP2ABCG2 | |
| SCHEMBL29961137 | 0.98 | TOP1 (0.78) | TOP1TERTCYCSENPP2ABCG2 | |
| SCHEMBL30915394 | 0.96 | TOP1 (0.76) | TOP1TERTCYCSENPP2ABCG2 | |
| Hydrochloric Acid SCHEMBL31627581 | 0.96 | TOP1 (0.76) | TOP1TERTCYCSENPP2ABCG2 | |
| SCHEMBL31313985 | 0.96 | TOP1 (0.76) | TOP1TERTCYCSENPP2ABCG2 | |
| SCHEMBL31313616 | 0.96 | TOP1 (0.76) | TOP1TERTCYCSENPP2ABCG2 | |
| Magnesium SCHEMBL31258521 | 0.96 | TOP1 (0.76) | TOP1TERTCYCSENPP2ABCG2 | |
| SCHEMBL2423633 | 0.96 | TOP1 (0.76) | TOP1TERTCYCSENPP2ABCG2 | |
| SCHEMBL600975 | 0.96 | TOP1 (0.76) | TOP1TERTCYCSENPP2ABCG2 | |
| Hydrochloric Acid SCHEMBL2101556 | 0.96 | TOP1 (0.76) | TOP1TERTCYCSENPP2ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2602655-B1 | Ophthalmic filter | ESSILOR INT (FR) | 2024-04-03 | — | — | EP | disclosed |
| US-11635547-B2 | Composition for the manufacture of an ophthalmic lens comprising an encapsulated light-absorbing additive | ESSILOR INTERNATIONAL (FR) | 2023-04-25 | — | — | US | disclosed |
| EP-2602654-B1 | Ophthalmic filter | ESSILOR INT (FR) | 2023-04-19 | — | — | EP | disclosed |
| EP-3497488-B2 | OPHTALMIC LENS COMPRISING AN ENCAPSULATED LIGHT-ABSORBING ADDITIVE | ESSILOR INT (FR) | 2023-03-22 | — | — | EP | disclosed |
| US-11327202-B2 | Composition for the manufacture of an ophthalmic lens comprising an encapsulated light-absorbing additive | ESSILOR INTERNATIONAL (FR) | 2022-05-10 | — | — | US | disclosed |