Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1011067 | 1.00 | PARP10 (0.42) | PARP10PARP11KDM4EMAPTMEN1 | |
| SCHEMBL1011370 | 0.81 | ALDH1A1 (0.47) | PARP10PARP11KDM4EMAPTMEN1 | |
| SCHEMBL33531892 | 0.79 | PARP10 (0.40) | PARP10PARP11KDM4EMEN1KMT2A | |
| SCHEMBL1010129 | 0.78 | CYP19A1 (0.41) | KDM4EMAPTMEN1KMT2AHTR2C | |
| SCHEMBL28163806 | 0.78 | PARP1 (0.42) | KDM4EMAPTMEN1KMT2AHTR2C | |
| SCHEMBL15487682 | 0.78 | KDM4E (0.40) | KDM4EMAPTMEN1KMT2AHTR2C | |
| SCHEMBL1009344 | 0.78 | CYP19A1 (0.41) | KDM4EMAPTMEN1KMT2AHTR2C | |
| SCHEMBL30167242 | 0.78 | CYP19A1 (0.41) | KDM4EMAPTMEN1KMT2AHTR2C | |
| SCHEMBL28164453 | 0.78 | PARP1 (0.42) | KDM4EMAPTMEN1KMT2AHTR2C | |
| SCHEMBL30878582 | 0.75 | HTR2C (0.55) | KDM4EMAPTHTR2CPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115867346-B | Kinase inhibitors | GB005股份有限公司 | 2025-03-14 | — | — | CN | disclosed |
| CN-114008032-B | Substituted tetrahydroisoquinoline derivatives as D1 positive allosteric modulators | UCB生物制药有限责任公司 | 2023-11-10 | — | — | CN | disclosed |
| EP-4267555-A1 | OCTAHYDROISOQUINOLINYL DERIVATIVES | UCB Biopharma SRL (BE) | 2023-11-01 | — | — | EP | disclosed |
| CN-116897150-A | Novel bifunctional molecules for protein-targeted degradation | 安菲斯塔治疗有限公司 | 2023-10-17 | — | — | CN | disclosed |
| CN-116507332-A | Octahydroisoquinolinyl derivatives | UCB生物制药有限责任公司 | 2023-07-28 | — | — | CN | disclosed |
| EP-4157446-A1 | KINASE INHIBITORS | GB002, Inc. (US) | 2023-04-05 | — | — | EP | disclosed |
| CN-115867346-A | Kinase inhibitors | GB005股份有限公司 | 2023-03-28 | — | — | CN | disclosed |
| CN-108884050-B | Tetrahydroisoquinoline derivatives | UCB生物制药私人有限公司 | 2022-07-05 | — | — | CN | disclosed |
| WO-2022117678-A1 | OCTAHYDROISOQUINOLINYL DERIVATIVES | UCB Biopharma SRL (BE) | 2022-06-09 | — | — | WO | disclosed |
| EP-3993795-A1 | A SUBSTITUTED TETRAHYDROISOQUINOLINE DERIVATIVE AS A D1 POSITIVE ALLOSTERIC MODULATOR | UCB Biopharma SRL (BE) | 2022-05-11 | — | — | EP | disclosed |