Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 7/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | KRAS | P01116 | 1/20 | 0.38 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | CCNK | O75909 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20711680 | 1.00 | PIK3CD (0.43) | PIK3CDPIK3CAPIK3CGPIK3CBTBK1 | |
| SCHEMBL30161519 | 1.00 | PIK3CD (0.43) | PIK3CDPIK3CAPIK3CGPIK3CBTBK1 | |
| SCHEMBL20699408 | 0.90 | RXRA (0.41) | PIK3CDPIK3CAPIK3CGPIK3CBRXRA | |
| SCHEMBL29606524 | 0.87 | PIK3CD (0.41) | PIK3CDPIK3CAPIK3CGPIK3CBTBK1 | |
| SCHEMBL20711770 | 0.87 | KRAS (0.39) | PIK3CDPIK3CAPIK3CGPIK3CBPDE4B | |
| SCHEMBL20711762 | 0.83 | PDE4B (0.43) | PIK3CDPIK3CAPIK3CGPIK3CBTBK1 | |
| SCHEMBL28385243 | 0.83 | PDE4B (0.43) | PIK3CDPIK3CAPIK3CGPIK3CBTBK1 | |
| SCHEMBL29607485 | 0.83 | PDE4B (0.43) | PIK3CDPIK3CAPIK3CGPIK3CBTBK1 | |
| SCHEMBL29003250 | 0.81 | RXRA (0.37) | KRASRXRARXRBRXRG | |
| SCHEMBL29003233 | 0.80 | RXRA (0.39) | PDE4BKRASRXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220119369-A1 | PYRAZOLO AND TRIAZOLO BICYCLIC COMPOUNDS AS JAK KINASE INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2022-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220119369-A1 | PYRAZOLO AND TRIAZOLO BICYCLIC COMPOUNDS AS JAK KINASE INHIBITORS | JAK3, JAK1, JAK2 | PIK3CD 207/4885PIK3CA 189/4885PIK3CG 220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.