Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 9/20 | 0.65 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.43 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22858828 | 1.00 | MAP4K1 (0.65) | MAP4K1TNIKMAP3K11AXLMERTK | |
| SCHEMBL22858727 | 0.94 | MAP4K1 (0.74) | MAP4K1TNIKMAP3K11JAK2JAK1 | |
| SCHEMBL29608816 | 0.94 | MAP4K1 (0.74) | MAP4K1TNIKMAP3K11JAK2JAK1 | |
| SCHEMBL22859134 | 0.90 | MAP4K1 (0.63) | MAP4K1TNIKMAP3K11AXLMERTK | |
| SCHEMBL29608963 | 0.89 | MAP4K1 (0.69) | MAP4K1TNIKMAP3K11AXLMERTK | |
| SCHEMBL22858921 | 0.89 | MAP4K1 (0.69) | MAP4K1TNIKMAP3K11AXLMERTK | |
| SCHEMBL22858705 | 0.89 | MAP4K1 (0.73) | MAP4K1TNIKMAP3K11JAK2JAK1 | |
| SCHEMBL22859000 | 0.89 | MAP4K1 (0.69) | MAP4K1TNIKMAP3K11AXLMERTK | |
| SCHEMBL22858731 | 0.88 | MAP4K1 (0.65) | MAP4K1TNIKMAP3K11AXLMERTK | |
| SCHEMBL22859215 | 0.88 | MAP4K1 (0.72) | MAP4K1TNIKMAP3K11JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12454534-B2 | Pyrrolo[2,3-b]pyrazines as HPK1 inhibitor and the use thereof | BEONE MEDICINES I GMBH (CH) | 2025-10-28 | — | — | US | disclosed |
| US-20220267333-A1 | PYRROLO[2,3-b]PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEONE MEDICINES I GMBH (CH) | 2022-08-25 | — | — | US | disclosed |
| EP-3994136-A1 | PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BeiGene, Ltd. (KY) | 2022-05-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220267333-A1 | PYRROLO[2,3-b]PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | PDXK, STK25, STK35 | MAP4K1 82/4885TNIK 120/4885MAP3K11 53/4885 |
| US-12454534-B2 | Pyrrolo[2,3-b]pyrazines as HPK1 inhibitor and the use thereof | PDXK, STK25, STK35 | MAP4K1 82/4885TNIK 120/4885MAP3K11 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.