Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 8/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 8/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 8/20 | 0.41 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 2/20 | 0.37 |
| ▸ | CDK4 | P11802 | 2/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24664466 | 1.00 | FGFR1 (0.41) | FGFR1FGFR2FGFR3MYLK4STK17A | |
| SCHEMBL30919959 | 0.77 | KIT (0.42) | CDK2CDK1CCNB1CCNE1 | |
| SCHEMBL29607254 | 0.76 | KDM5B (0.41) | CDK2CDK1CCNB1CCNE1CCNB2 | |
| SCHEMBL22852543 | 0.76 | KDM5B (0.41) | CDK2CDK1CCNB1CCNE1CCNB2 | |
| SCHEMBL24663775 | 0.76 | MYLK4 (0.50) | MYLK4STK17AEGFRCDK2CDK1 | |
| SCHEMBL24301059 | 0.76 | CCNC (0.49) | FGFR1FGFR2FGFR3EGFRMET | |
| SCHEMBL29528376 | 0.76 | CCNC (0.49) | FGFR1FGFR2FGFR3EGFRMET | |
| SCHEMBL30926322 | 0.76 | CDK1 (0.47) | FGFR1FGFR2FGFR3DYRK1AGSK3B | |
| SCHEMBL24663778 | 0.74 | FLT3 (0.53) | MYLK4STK17ACDK2CDK4CDK6 | |
| SCHEMBL17059212 | 0.74 | CCNE2 (0.49) | FGFR3CDK2CDK1CCNB1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114423750-B | 2, 4-Disubstituted pyrimidine derivative, preparation method and application thereof | 成都赜灵生物医药科技有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-114423750-A | 2, 4-disubstituted pyrimidine derivative and preparation method and application thereof | 成都赜灵生物医药科技有限公司 | 2022-04-29 | — | — | CN | disclosed |