Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | FER | P16591 | 1/20 | 0.41 |
| ▸ | LTK | P29376 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.40 |
| ▸ | CASP1 | P29466 | 5/20 | 0.40 |
| ▸ | CASP7 | P55210 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25302389 | 0.93 | CYP1A2 (0.45) | PARP1CYP1A2SMN1; SMN2PDGFRAFER | |
| SCHEMBL29029657 | 0.85 | PARP1 (0.53) | PARP1CYP1A2SMN1; SMN2ACVR1CASP1 | |
| SCHEMBL421641 | 0.75 | AHR (0.54) | CYP1A2PDGFRAFERLTKCDK8 | |
| SCHEMBL29428940 | 0.71 | PARP1 (0.72) | PARP1PDGFRAFERLTKCDK8 | |
| SCHEMBL302763 | 0.71 | PARP1 (0.72) | PARP1PDGFRAFERLTKCDK8 | |
| SCHEMBL30530523 | 0.70 | CDK5 (0.42) | PARP1CYP1A2SMN1; SMN2PDGFRAFER | |
| SCHEMBL24330117 | 0.70 | CDK5 (0.42) | PARP1CYP1A2SMN1; SMN2PDGFRAFER | |
| SCHEMBL24316070 | 0.70 | CCR1 (0.40) | PARP1CYP1A2SMN1; SMN2PDGFRAFER | |
| SCHEMBL24316072 | 0.69 | CYP1A2 (0.33) | CYP1A2SMN1; SMN2ALDH1A1HSD17B10ALOX15 | |
| SCHEMBL24315814 | 0.69 | PARP1 (0.36) | PARP1CYP1A2SMN1; SMN2PDGFRAFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4228639-A1 | TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 | C4 Therapeutics, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081925-A1 | TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |