Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 2/20 | 0.54 |
| ▸ | JAK1 | P23458 | 3/20 | 0.53 |
| ▸ | JAK3 | P52333 | 2/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | CDK9 | P50750 | 2/20 | 0.51 |
| ▸ | BRD4 | O60885 | 5/20 | 0.50 |
| ▸ | SYK | P43405 | 2/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | BTK | Q06187 | 2/20 | 0.47 |
| ▸ | WEE1 | P30291 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL340057 | 1.00 | CTSC (0.54) | CTSCJAK1JAK3JAK2CYP3A4 | |
| SCHEMBL341837 | 0.90 | JAK1 (0.66) | CTSCJAK1JAK3JAK2CYP3A4 | |
| SCHEMBL29610786 | 0.90 | JAK1 (0.66) | CTSCJAK1JAK3JAK2CYP3A4 | |
| SCHEMBL339911 | 0.86 | JAK1 (0.59) | CTSCJAK1JAK3JAK2CYP3A4 | |
| SCHEMBL29610683 | 0.86 | JAK1 (0.59) | CTSCJAK1JAK3JAK2CYP3A4 | |
| SCHEMBL340655 | 0.83 | JAK1 (0.61) | CTSCJAK1JAK3JAK2CYP3A4 | |
| SCHEMBL29610327 | 0.83 | JAK1 (0.61) | CTSCJAK1JAK3JAK2CYP3A4 | |
| SCHEMBL29610014 | 0.80 | JAK1 (0.83) | CTSCJAK1JAK3JAK2CYP3A4 | |
| SCHEMBL340094 | 0.80 | JAK1 (0.83) | CTSCJAK1JAK3JAK2CYP3A4 | |
| SCHEMBL3118591 | 0.78 | SYK (0.64) | CTSCJAK1JAK3JAK2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4009974-A1 | COMPOUNDS AND METHOD FOR TREATING CYTOKINE RELEASE SYNDROME | Rigel Pharmaceuticals, Inc. (US) | 2022-06-15 | — | — | EP | disclosed |