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SCHEMBL29611151

SCHEMBL29611151

COc1ccc(CNc2ncnc3c2c(-c2ccn(C)n2)cn3[C@@H]2O[C@H](C(=O)Nc3ccc4ccc(N(C)Cc5ccc(OC)cc5OC)nc4c3)[C@H]3OC(C)(C)O[C@H]32)c(OC)c1

nearest known ligand 0.45

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 7/20 0.45
▸ WDR77 Q9BQA1 7/20 0.45
▸ FLT3 P36888 1/20 0.45
▸ METTL3 Q86U44 15/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24313513 1.00 PRMT5 (0.45) PRMT5WDR77FLT3METTL3
SCHEMBL24313566 0.90 PRMT5 (0.58) PRMT5WDR77FLT3METTL3
SCHEMBL29610846 0.84 METTL3 (0.48) PRMT5WDR77METTL3
SCHEMBL29610961 0.84 METTL3 (0.48) PRMT5WDR77METTL3
SCHEMBL24313506 0.84 METTL3 (0.48) PRMT5WDR77METTL3
SCHEMBL29611585 0.84 METTL3 (0.49) PRMT5WDR77METTL3
SCHEMBL30642209 0.84 METTL3 (0.49) PRMT5WDR77METTL3
SCHEMBL29611629 0.83 PRMT5 (0.58) PRMT5WDR77METTL3
SCHEMBL30829021 0.83 PRMT5 (0.41) PRMT5WDR77FLT3METTL3
SCHEMBL27140726 0.83 PRMT5 (0.43) PRMT5WDR77METTL3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4229067-A1 METTL3 MODULATORS Accent Therapeutics, Inc. (US) 2023-08-23 — — EP disclosed
WO-2022081739-A1 METTL3 MODULATORS ACCENT THERAPEUTICS, INC. (US) 2022-04-21 — — WO disclosed
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