Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.79 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.46 |
| ▸ | TET3 | O43151 | 2/20 | 0.46 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.46 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.46 |
| ▸ | KDM4A | O75164 | 2/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.44 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.44 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL15441377 | 0.97 | SMN1; SMN2 (0.75) | SMN1; SMN2TP53TET2TET3TET1 | |
| Malic Acid SCHEMBL4435950 | 0.97 | SMN1; SMN2 (0.75) | SMN1; SMN2TP53TET2TET3TET1 | |
| Malic Acid SCHEMBL2467748 | 0.97 | SMN1; SMN2 (0.75) | SMN1; SMN2TP53TET2TET3TET1 | |
| Malic Acid SCHEMBL25375751 | 0.97 | SMN1; SMN2 (0.75) | SMN1; SMN2TP53TET2TET3TET1 | |
| Malic Acid SCHEMBL4615523 | 0.95 | SMN1; SMN2 (0.71) | SMN1; SMN2TP53TET2TET3TET1 | |
| Malic Acid SCHEMBL4615520 | 0.95 | SMN1; SMN2 (0.71) | SMN1; SMN2TP53TET2TET3TET1 | |
| Cadaverine Tartrate SCHEMBL18895372 | 0.93 | SMN1; SMN2 (0.68) | SMN1; SMN2TP53TET2TET3TET1 | |
| Malic Acid SCHEMBL28852027 | 0.92 | SMN1; SMN2 (0.83) | SMN1; SMN2TP53TET2TET3TET1 | |
| Malic Acid SCHEMBL29212744 | 0.91 | SMN1; SMN2 (0.65) | SMN1; SMN2TP53TET2TET3TET1 | |
| Malic Acid SCHEMBL16928437 | 0.90 | SMN1; SMN2 (0.71) | SMN1; SMN2TP53TET2TET3TET1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 312 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4030921-B1 | WHEY-BASED NUTRITIONAL COMPOSITIONS FORTIFIED WITH CALCIUM | NESTLE SA (CH) | 2024-02-21 | — | — | EP | claimed |
| CN-116836888-A | Lactobacillus kunmingensis with histamine degradation activity and L-malic acid conversion activity and application thereof in mulberry fruit wine | 广东省农业科学院蚕业与农产品加工研究所 | 2023-10-03 | — | — | CN | claimed |
| CN-116685211-A | Microbial cell product, method for obtaining microbial cell product and use of microbial cell product | 富美配料有限公司 | 2023-09-01 | — | — | CN | claimed |
| CN-116144437-A | Ageing method for enhancing complexity of grape wine | 宁夏昱豪酒庄有限公司 | 2023-05-23 | — | — | CN | claimed |
| CN-115960379-A | Preparation method and application of antibacterial polylysine film | 天津理工大学 | 2023-04-14 | — | — | CN | claimed |
| CN-111363699-B | Lactobacillus plantarum with both biological amine degradation activity and biological acid reduction activity and application of lactobacillus plantarum in fruit wine | 鲁东大学 | 2022-07-15 | — | — | CN | claimed |
| CN-111378605-B | Lactobacillus plantarum for biological deacidification of high-yield volatile ester compounds and application of lactobacillus plantarum in fruit wine | 鲁东大学 | 2022-05-10 | — | — | CN | claimed |
| CN-113249181-A | Aronia melanocarpa dry wine and brewing method thereof | 秦皇岛玛歌葡萄酿酒有限公司 | 2021-08-13 | — | — | CN | claimed |
| CN-106995766-B | Preparation method of selenium-rich fruit distilled liquor | 中国农业科学院果树研究所 | 2021-02-26 | — | — | CN | claimed |
| CN-111904902-A | Preparation method and formula of grape wine lees mask | 宁夏美酿生物科技有限公司 | 2020-11-10 | — | — | CN | claimed |
| CN-110669602-A | Brewing method of dry red wine of spine grape | 南方葡萄沟酒庄有限公司 | 2020-01-10 | — | — | CN | claimed |
| CN-108315150-A | A kind of brewing manufacture craft of morat | 唐山启森农业科技有限公司 | 2018-07-24 | — | — | CN | claimed |
| CN-105768201-A | Gum base type smoke-free tobacco product and preparation method thereof | 贵州中烟工业有限责任公司 | 2016-07-20 | — | — | CN | claimed |
| EP-2094097-B1 | EDIBLE AERATED OIL-AND-WATER EMULSION | UNILEVER NV (NL) | 2014-02-12 | — | — | EP | claimed |
| CN-102381875-A | Preparation method of double-perovskite ferroelectrics (FET)-antiferromagnetism (AFM) compound molecule with oxygen bridge | JIANPING ZONG | 2012-03-21 | — | — | CN | claimed |
| EP-2094097-A1 | EDIBLE AERATED OIL-AND-WATER EMULSION | UNILEVER N.V. (NL) | 2009-09-02 | — | — | EP | claimed |
| US-20080268131-A1 | Edible aerated oil-and-water emulsion | CONOPCO INC, D/B/A UNILEVER | 2008-10-30 | — | — | US | claimed |
| WO-2008080738-A1 | EDIBLE AERATED OIL-AND-WATER EMULSION | UNILEVER N.V. (NL) | 2008-07-10 | — | — | WO | claimed |
| US-6129925-A | Container filled with infusion liquids and infusion preparation | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2000-10-10 | — | — | US | claimed |
| US-5965616-A | SKIN CARE COMPOSITION WITH RETINOL AND AN ALPHA HYDROXYACID, TO AMELIORATES THE IRRITATING PROPERTIES OF RETINOL; NONIRRITATING | JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. (US) | 1999-10-12 | — | — | US | claimed |