Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.43 |
| ▸ | TET3 | O43151 | 2/20 | 0.43 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 2/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.41 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL4615520 | 1.00 | SMN1; SMN2 (0.71) | SMN1; SMN2TP53TET2TET3TET1 | |
| Malic Acid SCHEMBL4435950 | 0.98 | SMN1; SMN2 (0.75) | SMN1; SMN2TP53TET2TET3TET1 | |
| Malic Acid SCHEMBL29612 | 0.95 | SMN1; SMN2 (0.79) | SMN1; SMN2TP53TET2TET3TET1 | |
| Malic Acid SCHEMBL25375751 | 0.93 | SMN1; SMN2 (0.75) | SMN1; SMN2TP53TET2TET3TET1 | |
| Malic Acid SCHEMBL2467748 | 0.93 | SMN1; SMN2 (0.75) | SMN1; SMN2TP53TET2TET3TET1 | |
| Malic Acid SCHEMBL15441377 | 0.93 | SMN1; SMN2 (0.75) | SMN1; SMN2TP53TET2TET3TET1 | |
| Malic Acid SCHEMBL29008345 | 0.90 | SMN1; SMN2 (0.88) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Cadaverine Tartrate SCHEMBL18895372 | 0.88 | SMN1; SMN2 (0.68) | SMN1; SMN2TP53TET2TET3TET1 | |
| Malic Acid SCHEMBL11134433 | 0.87 | SMN1; SMN2 (0.83) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL10951681 | 0.87 | SMN1; SMN2 (0.83) | SMN1; SMN2TET2TET3TET1SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1449519-B1 | Liquid composition containing a guanidine amide group derivative and/or a salt thereof | AJINOMOTO KK (JP) | 2008-07-09 | — | — | EP | disclosed |