Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 20/20 | 0.84 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535 | 0.91 | ALOX5AP (1.00) | ALOX5APPTGS1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL30585982 | 0.91 | ALOX5AP (1.00) | ALOX5APPTGS1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL2936036 | 0.91 | ALOX5AP (0.99) | ALOX5APPTGS1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL2961349 | 0.91 | ALOX5AP (0.69) | ALOX5APPTGS1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL2974070 | 0.90 | ALOX5AP (0.87) | ALOX5APPTGS1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL5530857 | 0.90 | ALOX5AP (0.86) | ALOX5APPTGS1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL13767438 | 0.89 | ALOX5AP (0.85) | ALOX5APPTGS1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL13415377 | 0.89 | ALOX5AP (0.90) | ALOX5APPTGS1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL13415378 | 0.89 | ALOX5AP (0.90) | ALOX5APPTGS1CYP2C9CYP3A4CYP2D6 | |
| Lithium Ion SCHEMBL2936035 | 0.87 | ALOX5AP (0.87) | ALOX5APPTGS1CYP2C9CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212312-A2 | 5-LIPOXYGENASE ACTIVATING PROTEIN (FLAP) INHIBITOR | Amira Pharmaceuticals, Inc. (US) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009055721-A2 | 5-LIPOXYGENASE ACTIVATING PROTEIN (FLAP) INHIBITOR | AMIRA PHARMACEUTICALS, INC. (US) | 2009-04-30 | — | — | WO | disclosed |