Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 20/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.89 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.83 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30585982 | 1.00 | ALOX5AP (1.00) | ALOX5APPTGS1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL2936036 | 0.99 | ALOX5AP (0.99) | ALOX5APPTGS1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL13415377 | 0.94 | ALOX5AP (0.90) | ALOX5APPTGS1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL13415378 | 0.94 | ALOX5AP (0.90) | ALOX5APPTGS1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL1721814 | 0.94 | ALOX5AP (0.89) | ALOX5APPTGS1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL169843 | 0.94 | ALOX5AP (1.00) | ALOX5APPTGS1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL170294 | 0.94 | ALOX5AP (0.88) | ALOX5APPTGS1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL2974070 | 0.93 | ALOX5AP (0.87) | ALOX5APPTGS1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL3057383 | 0.93 | ALOX5AP (0.87) | ALOX5APPTGS1CYP2C9CYP3A4CYP2D6 | |
| SCHEMBL3057395 | 0.93 | ALOX5AP (0.87) | ALOX5APPTGS1CYP2C9CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 220 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024264025-A2 | THERAPEUTIC TARGETING OF HYPDH/PRODH2 AND PRODH1 TO SUPPRESS 4-HYDROXYPROLINE AND PROLINE CATABOLISM | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2024-12-26 | — | — | WO | claimed |
| US-20230390232-A1 | N-PROPARGYLGLYCINE: A UNIQUE INHIBITOR OF PROLINE DEHYDROGENASE WITH BRAIN-ENHANCING MITOHORMESIS PROPERTIES CAPABLE OF MITIGATING THE PATHOGENESIS OF NEURODEGENERATIVE DISORDERS | NATIONAL INSTITUTES OF HEALTH | 2023-12-07 | — | — | US | claimed |
| CN-113476614-B | Homopolymeric electrolyte composite vesicle, preparation method thereof, antibacterial vesicle, vesicle coated with hydrophobic substance and anti-adhesion vesicle | 青岛科技大学 | 2023-08-25 | — | — | CN | claimed |
| WO-2023279594-A1 | HOMOPOLYMER ELECTROLYTE COMPOSITE VESICLE, PREPARATION METHOD THEREFOR, ANTIBACTERIAL VESICLE, VESICLE CONTAINING HYDROPHOBIC SUBSTANCES AND ANTI-ADHESION VESICLE | 青岛科技大学 | 2023-01-12 | — | — | WO | claimed |
| CN-113476614-A | Uniform polyelectrolyte composite vesicle and preparation method thereof, antibacterial vesicle, hydrophobic substance-encapsulated vesicle and anti-adhesion vesicle | 青岛科技大学 | 2021-10-08 | — | — | CN | claimed |
| US-20200147064-A1 | Reduction of Pro-Inflammatory HDL Using a Leukotriene Inhibitor | AUTOIMMUNE PHARMA LLC (US) | 2020-05-14 | — | — | US | claimed |
| WO-2018152405-A1 | REDUCTION OF PRO-INFLAMMATORY HDL USING A LEUKOTRIENE INHIBITOR | AUTOIMMUNE PHARMA LLC (US) | 2018-08-23 | — | — | WO | claimed |
| US-20170348266-A1 | INHIBITION OF PROLINE CATABOLISM FOR THE TREATMENT OF CANCER AND OTHER THERAPEUTIC APPLICATIONS | BUCK INSTITUTE FOR RESEARCH ON AGING | 2017-12-07 | — | — | US | claimed |
| WO-2016077632-A2 | INHIBITION OF PROLINE CATABOLISM FOR THE TREATMENT OF CANCER AND OTHER THERAPEUTIC APPLICATIONS | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2016-05-19 | — | — | WO | claimed |
| US-8546431-B2 | 5-lipoxygenase-activating protein (FLAP) inhibitors | PANMIRA PHARMACEUTICALS, LLC (US) | 2013-10-01 | — | — | US | claimed |
| US-20070219206-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | AMIRA PHARMACEUTICALS, INC. (US) | 2007-09-20 | — | — | US | claimed |
| US-20070105866-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | AMIRA PHARMACEUTICALS, INC. (US) | 2007-05-10 | — | — | US | claimed |
| US-7115543-B2 | Aryl sulfonyl amino carbonyl triazole based selective herbicides | BAYER CROPSCIENCE AG (DE) | 2006-10-03 | — | — | US | claimed |
| US-20050192182-A1 | Herbicidal mixtures based on substituted aryl ketones | BAYER CROPSCIENCE AG (DE) | 2005-09-01 | — | — | US | claimed |
| EP-1303189-B1 | ARYL SULFONYL AMINO CARBONYL TRIAZOLE BASED SELECTIVE HERBICIDES | BAYER CROPSCIENCE AG (DE) | 2005-08-24 | — | — | EP | claimed |
| US-20050090397-A1 | Herbicides made from substituted aryl ketones | BAYER CROPSCIENCE AG (GB) | 2005-04-28 | — | — | US | claimed |
| US-20050009705-A1 | Selective herbicides based on substituted thien-3-yl-sulfonylamino(thio)carbonyltriazolin(thi)ones and safeners | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2005-01-13 | — | — | US | claimed |
| US-6770599-B2 | Tetrazole derivatives | BAYER CROPSCIENCE KK (JP) | 2004-08-03 | — | — | US | claimed |
| US-20040116294-A1 | Herbicides based on substituted aryl ketones | BAYER CROPSCIENCE AG (DE) | 2004-06-17 | — | — | US | claimed |
| US-20030211942-A1 | Aryl sulfonyl amino carbonyl triazole based selective herbicides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2003-11-13 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105866-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | ALOX5, ALOX15B, ALOX15 | ALOX5AP 4/4885PTGS1 27/4885CYP2C9 2125/4885 |
| US-20050192182-A1 | Herbicidal mixtures based on substituted aryl ketones | DDT, CBR3, CYP1B1 | ALOX5AP 4229/4885PTGS1 3734/4885CYP2C9 58/4885 |
| US-20170348266-A1 | INHIBITION OF PROLINE CATABOLISM FOR THE TREATMENT OF CANCER AND OTHER THERAPEUTIC APPLICATIONS | GLUL, GLS2, PHGDH | ALOX5AP 4270/4885PTGS1 928/4885CYP2C9 2684/4885 |
| US-20030211942-A1 | Aryl sulfonyl amino carbonyl triazole based selective herbicides | AADAC, CBR3, ABAT | ALOX5AP 2988/4885PTGS1 4457/4885CYP2C9 578/4885 |
| US-20050090397-A1 | Herbicides made from substituted aryl ketones | DDT, CBR3, CBR1 | ALOX5AP 3791/4885PTGS1 3666/4885CYP2C9 103/4885 |
| US-20050009705-A1 | Selective herbicides based on substituted thien-3-yl-sulfonylamino(thio)carbonyltriazolin(thi)ones and safeners | TARS2, TST, DDT | ALOX5AP 4117/4885PTGS1 3466/4885CYP2C9 230/4885 |
| US-20200147064-A1 | Reduction of Pro-Inflammatory HDL Using a Leukotriene Inhibitor | LTB4R, LTC4S, LTB4R2 | ALOX5AP 35/4885PTGS1 22/4885CYP2C9 619/4885 |
| US-20070219206-A1 | 5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS | ALOX5, ALOX15B, ALOX15 | ALOX5AP 4/4885PTGS1 27/4885CYP2C9 2125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.