Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | IDE | P14735 | 1/20 | 0.47 |
| ▸ | MPI | P34949 | 1/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TNKS | O95271 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | GPR3 | P46089 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11214071 | 0.79 | PDE10A (0.44) | KDM4EALDH1A1MAPTIDEMPI | |
| SCHEMBL6818663 | 0.74 | PARP1 (0.52) | KDM4EALDH1A1MAPTIDEMPI | |
| SCHEMBL4820228 | 0.73 | KDM4E (0.56) | KDM4EALDH1A1MAPTIDEMPI | |
| Benzoylenurea SCHEMBL4559940 | 0.73 | ALDH1A1 (0.50) | KDM4EALDH1A1MAPTIDEMPI | |
| SCHEMBL6887071 | 0.72 | ALDH1A1 (0.52) | KDM4EALDH1A1MAPTIDEMPI | |
| SCHEMBL30014118 | 0.71 | NPC1 (0.52) | KDM4EALDH1A1MAPTIDEMPI | |
| SCHEMBL577953 | 0.71 | NPC1 (0.52) | KDM4EALDH1A1MAPTIDEMPI | |
| SCHEMBL30561826 | 0.70 | ALDH1A1 (0.49) | KDM4EALDH1A1MAPTIDEMPI | |
| SCHEMBL3253183 | 0.69 | ALDH1A1 (0.48) | KDM4EALDH1A1MAPTIDEMPI | |
| SCHEMBL103993 | 0.69 | ALDH1A1 (0.53) | KDM4EALDH1A1MAPTPARP1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7763605-B2 | [1,4]benzodiazepines as vasopressin V2 receptor antagonists | JANSSEN PHARMACEUTICA, N.V. (BE) | 2010-07-27 | — | — | US | disclosed |
| EP-1809296-A4 | NOVEL [1,4]BENZODIAZEPINES AS VASOPRESSIN V2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2009-03-11 | — | — | EP | disclosed |
| EP-1809296-A2 | NOVEL [1,4]BENZODIAZEPINES AS VASOPRESSIN V2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-25 | — | — | EP | disclosed |
| US-20060116367-A1 | Novel [1,4]benzodiazepines as vasopressin V2 receptor antagonists | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-06-01 | — | — | US | disclosed |
| WO-2006049984-A2 | NOVEL [1,4]BENZODIAZEPINES AS VASOPRESSIN V2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116367-A1 | Novel [1,4]benzodiazepines as vasopressin V2 receptor antagonists | AVPR2, AVPR1B, AVPR1A | KDM4E 4029/4885ALDH1A1 1829/4885MAPT 3693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.