Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.59 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20051584 | 1.00 | GRM5 (0.59) | GRM5NOTUMDRD2DRD3USP30 | |
| SCHEMBL27291135 | 0.80 | MAPKAPK2 (0.43) | GRM5NOTUMNSD2 | |
| SCHEMBL29794847 | 0.80 | GRM5 (0.54) | GRM5NOTUMUSP30 | |
| SCHEMBL20594437 | 0.80 | GRM5 (0.54) | GRM5NOTUMUSP30 | |
| SCHEMBL23603987 | 0.78 | GRM5 (0.55) | GRM5NOTUMDRD2DRD3USP30 | |
| SCHEMBL11467421 | 0.76 | GRM5 (0.58) | GRM5NOTUMDRD2DRD3NSD2 | |
| SCHEMBL31316756 | 0.76 | GRM5 (0.58) | GRM5NOTUMDRD2DRD3NSD2 | |
| SCHEMBL29614966 | 0.76 | GRM5 (0.53) | GRM5NOTUMDRD2DRD3USP30 | |
| SCHEMBL23198257 | 0.76 | GRM5 (0.53) | GRM5NOTUMDRD2DRD3USP30 | |
| SCHEMBL5202469 | 0.75 | GRM5 (1.00) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115279741-A | 4-phenyl-N- (phenyl) thiazol-2-amine derivatives and related compounds as Aryl Hydrocarbon Receptor (AHR) agonists for the treatment of, for example, angiogenesis-related disorders or inflammatory disorders | 医肯纳肿瘤学公司 | 2022-11-01 | — | — | CN | disclosed |
| CN-109803963-B | Cyano-substituted heterocycles having USP30 inhibitor activity | 特殊治疗有限公司 | 2022-04-26 | — | — | CN | disclosed |