Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.54 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20594437 | 1.00 | GRM5 (0.54) | GRM5USP30NOTUMTP53SMN1; SMN2 | |
| SCHEMBL30309900 | 0.84 | NOTUM (0.58) | GRM5USP30NOTUMTP53SMN1; SMN2 | |
| SCHEMBL20594696 | 0.84 | NOTUM (0.58) | GRM5USP30NOTUMTP53SMN1; SMN2 | |
| SCHEMBL15464739 | 0.82 | ACKR3 (0.47) | USP30NOTUMTP53SMN1; SMN2MAPT | |
| SCHEMBL29614947 | 0.80 | GRM5 (0.59) | GRM5USP30NOTUM | |
| SCHEMBL20051584 | 0.80 | GRM5 (0.59) | GRM5USP30NOTUM | |
| SCHEMBL15019823 | 0.80 | MAPT (0.50) | NOTUMTP53SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL3529890 | 0.78 | SMN1; SMN2 (0.57) | USP30TP53SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL15019741 | 0.78 | SMN1; SMN2 (0.45) | NOTUMTP53SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL15019455 | 0.78 | TP53 (0.52) | NOTUMTP53SMN1; SMN2MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110831936-B | Substituted cyanopyrrolidines with DUB inhibitor activity | 特殊治疗有限公司 | 2023-03-28 | — | — | CN | disclosed |
| EP-3642196-B1 | SUBSTITUTED CYANOPYRROLIDINES WITH ACTIVITY AS DUB INHIBITORS | MISSION THERAPEUTICS LTD (GB) | 2022-08-17 | — | — | EP | disclosed |