Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 4/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19911752 | 1.00 | HTR1B (0.41) | HTR1BCD274KDM4EALDH1A1MEN1 | |
| SCHEMBL19939445 | 0.86 | CYP2D6 (0.52) | CD274KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL19897545 | 0.84 | KDM4E (0.44) | HTR1BKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL19939871 | 0.82 | CYP2D6 (0.48) | CD274KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL19939438 | 0.82 | KDM4E (0.34) | HTR1BKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL19897514 | 0.81 | CD274 (0.51) | CD274KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL19939510 | 0.80 | CYP2D6 (0.46) | CD274KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL19939874 | 0.80 | SYK (0.40) | KDM4EMEN1KMT2ARECQLNPSR1 | |
| SCHEMBL19939448 | 0.78 | KCNA5 (0.44) | — | |
| SCHEMBL19897622 | 0.78 | CD274 (0.49) | CD274KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3507284-B1 | BIARYL COMPOUNDS USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2022-05-25 | — | — | EP | claimed |
| EP-3507284-B1 | BIARYL COMPOUNDS USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2022-05-25 | — | — | EP | disclosed |