Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK3 | O43781 | 4/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.56 |
| ▸ | CDK9 | P50750 | 4/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.56 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.56 |
| ▸ | DYRK2 | Q92630 | 4/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.56 |
| ▸ | CDK2 | P24941 | 3/20 | 0.56 |
| ▸ | FYN | P06241 | 7/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.39 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1202668 | 0.85 | DYRK3 (0.48) | DYRK3CCNT1CDK9CDK5DYRK1A | |
| SCHEMBL16009418 | 0.84 | DYRK3 (0.77) | DYRK3CCNT1CDK9CDK5DYRK1A | |
| SCHEMBL21643998 | 0.78 | DYRK3 (0.67) | DYRK3CCNT1CDK9CDK5DYRK1A | |
| SCHEMBL2903376 | 0.75 | FYN (0.71) | FYN | |
| SCHEMBL15288066 | 0.73 | MKNK1 (0.67) | DYRK3CCNT1CDK9CDK5DYRK1A | |
| SCHEMBL16010568 | 0.73 | FYN (0.69) | DYRK3CCNT1CDK9CDK5DYRK1A | |
| SCHEMBL16023603 | 0.72 | CCNT1 (0.73) | DYRK3CCNT1CDK9CDK5DYRK1A | |
| SCHEMBL16010529 | 0.72 | DYRK1A (1.00) | DYRK3CCNT1CDK9CDK5DYRK1A | |
| SCHEMBL14881421 | 0.71 | FYN (0.61) | DYRK3CCNT1CDK9CDK5DYRK1A | |
| SCHEMBL16265339 | 0.71 | FYN (0.57) | FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217601-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | Centro Nacional de Investigaciones Oncológicas (CNIO) (ES) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009060197-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2009-05-14 | — | — | WO | disclosed |