Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 20/20 | 0.83 |
| ▸ | KCNH2 | Q12809 | 13/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.83 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2955877 | 1.00 | MCHR1 (0.83) | MCHR1KCNH2CYP3A4MCHR2 | |
| SCHEMBL2955875 | 1.00 | MCHR1 (0.83) | MCHR1KCNH2CYP3A4MCHR2 | |
| Hydrochloric Acid SCHEMBL2955786 | 0.99 | MCHR1 (0.82) | MCHR1KCNH2CYP3A4MCHR2 | |
| Hydrochloric Acid SCHEMBL2955787 | 0.99 | MCHR1 (0.82) | MCHR1KCNH2CYP3A4MCHR2 | |
| Hydrochloric Acid SCHEMBL2961561 | 0.99 | MCHR1 (0.82) | MCHR1KCNH2CYP3A4MCHR2 | |
| SCHEMBL2959820 | 0.95 | MCHR1 (0.84) | MCHR1KCNH2CYP3A4MCHR2 | |
| SCHEMBL12340342 | 0.91 | MCHR1 (0.82) | MCHR1KCNH2CYP3A4 | |
| SCHEMBL2958131 | 0.91 | MCHR1 (1.00) | MCHR1KCNH2CYP3A4MCHR2 | |
| SCHEMBL2964660 | 0.91 | MCHR1 (1.00) | MCHR1KCNH2CYP3A4MCHR2 | |
| SCHEMBL2958126 | 0.91 | MCHR1 (1.00) | MCHR1KCNH2CYP3A4MCHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268868-B2 | 5-pyridinone substituted indazoles | ALBANY MOLECULAR RESEARCH, INC. (US) | 2012-09-18 | — | — | US | disclosed |
| US-8268868-B2 | 5-pyridinone substituted indazoles | ALBANY MOLECULAR RESEARCH, INC. (US) | 2012-09-18 | — | — | US | disclosed |
| US-8268868-B2 | 5-pyridinone substituted indazoles | ALBANY MOLECULAR RESEARCH, INC. (US) | 2012-09-18 | — | — | US | disclosed |
| US-20100105679-A1 | 5-PYRIDINONE SUBSTITUTED INDAZOLES | ALBANY MOLECULAR RESEARCH, INC. (US) | 2010-04-29 | — | — | US | disclosed |
| US-20100105679-A1 | 5-PYRIDINONE SUBSTITUTED INDAZOLES | ALBANY MOLECULAR RESEARCH, INC. (US) | 2010-04-29 | — | — | US | disclosed |
| US-20100105679-A1 | 5-PYRIDINONE SUBSTITUTED INDAZOLES | ALBANY MOLECULAR RESEARCH, INC. (US) | 2010-04-29 | — | — | US | disclosed |
| WO-2008086404-A1 | 5-PYRIDINONE SUBSTITUTED INDAZOLES | ALBANY MOLECULAR RESEARCH, INC. (US) | 2008-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105679-A1 | 5-PYRIDINONE SUBSTITUTED INDAZOLES | CYP3A5, PDXK, PNPO | MCHR1 4525/4885KCNH2 917/4885CYP3A4 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.