Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 13/20 | 0.54 |
| ▸ | KIT | P10721 | 12/20 | 0.54 |
| ▸ | SRC | P12931 | 3/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.54 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | SIK1 | P57059 | 1/20 | 0.46 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.46 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22917725 | 0.89 | KIT (0.49) | FLT3KITSRCNTRK1LIMK1 | |
| SCHEMBL29616407 | 0.89 | KIT (0.49) | FLT3KITSRCNTRK1LIMK1 | |
| SCHEMBL22917727 | 0.89 | KIT (0.49) | FLT3KITSRCNTRK1LIMK1 | |
| SCHEMBL22917509 | 0.88 | KIT (0.49) | FLT3KITSRCNTRK1LIMK1 | |
| SCHEMBL22917522 | 0.86 | KIT (0.54) | FLT3KITSRCNTRK1LIMK1 | |
| SCHEMBL29539419 | 0.85 | KIT (0.57) | FLT3KITSRCNTRK1LIMK1 | |
| SCHEMBL22917465 | 0.85 | KIT (0.57) | FLT3KITSRCNTRK1LIMK1 | |
| SCHEMBL29616393 | 0.84 | FLT3 (0.51) | FLT3KITSRCNTRK1LIMK1 | |
| SCHEMBL29616288 | 0.84 | FLT3 (0.51) | FLT3KITSRCNTRK1LIMK1 | |
| SCHEMBL29616211 | 0.84 | FLT3 (0.51) | FLT3KITSRCNTRK1LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3999064-A1 | INHIBITORS OF TYROSINE KINASE | Bridgene Biosciences, Inc. (US) | 2022-05-25 | — | — | EP | disclosed |