Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.65 |
| ▸ | CES1 | P23141 | 1/20 | 0.65 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.64 |
| ▸ | PARP1 | P09874 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31167605 | 0.85 | ABCG2 (0.78) | CES2CES1ABCG2PARP1MAOB | |
| SCHEMBL2327652 | 0.84 | CES2 (0.67) | CES2CES1ABCG2PARP1MAOB | |
| Water SCHEMBL1894563 | 0.82 | CES2 (0.65) | CES2CES1ABCG2PARP1MAOB | |
| SCHEMBL14619169 | 0.82 | CES2 (0.65) | CES2CES1ABCG2PARP1MAOB | |
| SCHEMBL27278656 | 0.81 | MAPT (0.47) | CES2CES1ABCG2PARP1MAOB | |
| SCHEMBL6347273 | 0.81 | ABCG2 (0.58) | CES2CES1ABCG2NPC1RAB9A | |
| SCHEMBL18674567 | 0.81 | CES2 (0.62) | CES2CES1ABCG2PARP1MAOB | |
| SCHEMBL30641502 | 0.81 | ABCG2 (0.71) | CES2CES1ABCG2PARP1MAOB | |
| SCHEMBL21843730 | 0.81 | ABCG2 (0.71) | CES2CES1ABCG2PARP1MAOB | |
| SCHEMBL16952755 | 0.80 | NPC1 (0.58) | CES2CES1ABCG2PARP1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112321523-B | Preparation method and application of oxazolone compound capable of inhibiting bacteria in patient care process | 河南科技大学第一附属医院 | 2021-04-30 | — | — | CN | claimed |
| CN-112321523-A | Preparation method and application of oxazolone compound capable of inhibiting bacteria in patient care process | 河南科技大学第一附属医院 | 2021-02-05 | — | — | CN | claimed |
| CN-111559985-A | Oxazolone compound with bactericidal effect and preparation method thereof | 河南科技大学第一附属医院 | 2020-08-21 | — | — | CN | claimed |
| US-20250320201-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | AGIOS PHARMACEUTICALS INC (US) | 2025-10-16 | — | — | US | disclosed |
| CN-112321523-B | Preparation method and application of oxazolone compound capable of inhibiting bacteria in patient care process | 河南科技大学第一附属医院 | 2021-04-30 | — | — | CN | disclosed |
| CN-112321523-A | Preparation method and application of oxazolone compound capable of inhibiting bacteria in patient care process | 河南科技大学第一附属医院 | 2021-02-05 | — | — | CN | disclosed |
| CN-111559985-A | Oxazolone compound with bactericidal effect and preparation method thereof | 河南科技大学第一附属医院 | 2020-08-21 | — | — | CN | disclosed |
| CN-105541582-B | The MBH of alpha, beta unsaturated ketone and allyl acetic acid ester reacts | 浙江大学 | 2017-07-18 | — | — | CN | disclosed |
| US-9663516-B2 | Bicyclic-pyrimidinedione compounds | MyoKardia, Inc. (US) | 2017-05-30 | — | — | US | disclosed |
| US-9663516-B2 | Bicyclic-pyrimidinedione compounds | MyoKardia, Inc. (US) | 2017-05-30 | — | — | US | disclosed |
| US-9663516-B2 | Bicyclic-pyrimidinedione compounds | MyoKardia, Inc. (US) | 2017-05-30 | — | — | US | disclosed |
| EP-1723116-B1 | TETRAHYDROQUINOLINONES AND THEIR USE AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO KGAA (DE) | 2008-09-24 | — | — | EP | disclosed |
| EP-1723116-A2 | TETRAHYDROQUINOLINONES AND THEIR USE AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co. KGaA (DE) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005082856-A2 | TETRAHYDROQUINOLINONES AND THEIR USE AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2005-09-09 | — | — | WO | disclosed |
| US-20050197361-A1 | Specific binding is extremely high; low toxicity; high degree of activity; 2-(5-m-Tolyl-thiazol-2-yl )-7,8-dihydro-6H-quinolin-5-one, acute and/or chronic neurological disorders | MERZ PHARMA GMBH & CO. KGAA (DE) | 2005-09-08 | — | — | US | disclosed |
| CN-1015178-B | PROCESS AND INTERMEDIATES FOR BETA-LACTAM ANTIBIOTICS | HARVARD COLLEGE (US) | 1991-12-25 | — | — | CN | disclosed |
| CN-86104783-A | The method for preparing beta-Lactam antibiotics | — | 1987-02-04 | — | — | CN | disclosed |
| US-4236005-A | ANTIANXIETY | AMERICAN CYANAMID COMPANY (US) | 1980-11-25 | — | — | US | disclosed |
| US-4209621-A | TRANQUILIZERS | AMERICAN CYANAMID COMPANY (US) | 1980-06-24 | — | — | US | disclosed |
| US-4178449-A | Pyrazolo[1,5-a]pyrimidines and imidazo-[1,5-a]pyrimidines | AMERICAN CYANAMID COMPANY (US) | 1979-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250320201-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | PAH, KDM8, PHF8 | CES2 2732/4885CES1 1501/4885ABCG2 1412/4885 |
| US-20050197361-A1 | Specific binding is extremely high; low toxicity; high degree of activity; 2-(5-m-Tolyl-thiazol-2-yl )-7,8-dihydro-6H-quinolin-5-one, acute and/or chronic neurological disorders | GRM5, GRIK5, GRIN2C | CES2 2443/4885CES1 2965/4885ABCG2 100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.