Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 9/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23148999 | 1.00 | POLQ (0.44) | POLQDAOKDM4EALDH1A1MAPT | |
| SCHEMBL18280121 | 0.88 | SRD5A2 (0.40) | POLQCES2EGFRMEN1KMT2A | |
| SCHEMBL28736930 | 0.85 | IDO1 (0.48) | POLQDAOEGFRMEN1KMT2A | |
| SCHEMBL10823319 | 0.84 | DAO (0.41) | DAOMAPTEGFRMEN1KMT2A | |
| SCHEMBL22462892 | 0.84 | LMNA (0.40) | POLQMAPTEGFRMEN1KMT2A | |
| SCHEMBL24357851 | 0.84 | LMNA (0.38) | MAPTEGFRKMT2ANPSR1LMNA | |
| SCHEMBL27401901 | 0.83 | ANO1 (0.41) | ALDH1A1EGFRMEN1KMT2ANPSR1 | |
| SCHEMBL30836007 | 0.83 | ANO1 (0.41) | ALDH1A1EGFRMEN1KMT2ANPSR1 | |
| SCHEMBL11206400 | 0.81 | EGFR (0.34) | POLQMAPTEGFREPHX2 | |
| SCHEMBL11202572 | 0.81 | DDR1 (0.35) | ALDH1A1EGFRMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4034538-A1 | NEW HETEROCYCLIC MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2022-08-03 | — | — | EP | disclosed |
| CN-114401968-A | Novel heterocyclic monoacylglycerol lipase (MAGL) inhibitors | 豪夫迈·罗氏有限公司 | 2022-04-26 | — | — | CN | disclosed |