Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.40 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23148979 | 1.00 | PDE2A (0.44) | PDE2AALDH1A1MAPTJAK2JAK1 | |
| SCHEMBL28571714 | 0.80 | GPR27 (0.55) | ALDH1A1MAPTJAK2JAK1TYK2 | |
| SCHEMBL17814063 | 0.79 | PDE2A (0.46) | PDE2AALDH1A1MAPTSORT1AVPR2 | |
| SCHEMBL29616566 | 0.76 | SMN1; SMN2 (0.50) | ALDH1A1MAPTJAK2JAK1TYK2 | |
| SCHEMBL4145427 | 0.76 | SMN1; SMN2 (0.50) | ALDH1A1MAPTJAK2JAK1TYK2 | |
| SCHEMBL4357462 | 0.75 | AVPR2 (0.50) | PDE2AALDH1A1MAPTJAK2JAK1 | |
| SCHEMBL4680773 | 0.74 | FLT1 (0.43) | ALDH1A1LMNAMEN1HTTKMT2A | |
| SCHEMBL3276332 | 0.74 | HSD17B10 (0.46) | ALDH1A1MAPTCES2LMNAHTT | |
| SCHEMBL4511425 | 0.73 | P2RX1 (0.53) | ALDH1A1MAPTJAK2JAK1TYK2 | |
| SCHEMBL1818435 | 0.73 | KDM4E (0.62) | PDE2AALDH1A1SORT1AVPR2GPR27 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114401968-A | Novel heterocyclic monoacylglycerol lipase (MAGL) inhibitors | 豪夫迈·罗氏有限公司 | 2022-04-26 | — | — | CN | disclosed |