Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 1.00 |
| ▸ | BTK | Q06187 | 10/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18665653 | 1.00 | EGFR (1.00) | EGFRBTK | |
| SCHEMBL18665651 | 0.90 | EGFR (1.00) | EGFRBTK | |
| SCHEMBL29886851 | 0.88 | BTK (0.84) | EGFRBTK | |
| SCHEMBL18665673 | 0.88 | BTK (0.84) | EGFRBTK | |
| SCHEMBL24735215 | 0.86 | EGFR (0.86) | EGFRBTK | |
| SCHEMBL18665608 | 0.86 | EGFR (1.00) | EGFRBTK | |
| SCHEMBL29841335 | 0.86 | EGFR (0.86) | EGFRBTK | |
| SCHEMBL31071137 | 0.86 | EGFR (0.75) | EGFRBTK | |
| SCHEMBL25378572 | 0.85 | EGFR (0.89) | EGFRBTK | |
| SCHEMBL31611556 | 0.85 | EGFR (0.89) | EGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4116303-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS BTK INHIBITORS FOR THE TREATMENT OF CANCER | Loxo Oncology, Inc. (US) | 2023-01-11 | — | — | EP | disclosed |
| CN-114685516-A | Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer | 洛克索肿瘤学股份有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-108431007-B | Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer | 洛克索肿瘤学股份有限公司 | 2022-06-07 | — | — | CN | disclosed |