Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SNR3C2
The experimentally established mechanism targets of (R)-Felodipine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C known ✓ | Q13936 | 2/20 | 0.61 |
| ▸ | CACNA1F known ✓ | O60840 | 1/20 | 0.58 |
| ▸ | CACNA1D known ✓ | Q01668 | 1/20 | 0.58 |
| ▸ | CACNA1S known ✓ | Q13698 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 5/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 4/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 3/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 3/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 3/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Felodipine SCHEMBL13460298 | 1.00 | CYP2C9 (1.00) | CYP2C9CYP3A4HIF1AKDM4EMEN1 | |
| Felodipine SCHEMBL920025 | 1.00 | CYP2C9 (1.00) | CYP2C9CYP3A4HIF1AKDM4EMEN1 | |
| (S)-Felodipine SCHEMBL26399 | 1.00 | CYP2C9 (1.00) | CYP2C9CYP3A4HIF1AKDM4EMEN1 | |
| Felodipine SCHEMBL26398 | 1.00 | CYP2C9 (1.00) | CYP2C9CYP3A4HIF1AKDM4EMEN1 | |
| (R)-Felodipine SCHEMBL54486 | 1.00 | CYP2C9 (1.00) | CYP2C9CYP3A4HIF1AKDM4EMEN1 | |
| (S)-Felodipine SCHEMBL29908048 | 1.00 | CYP2C9 (1.00) | CYP2C9CYP3A4HIF1AKDM4EMEN1 | |
| Felodipine SCHEMBL29049073 | 0.99 | CYP2C9 (0.98) | CYP2C9CYP3A4HIF1AKDM4EMEN1 | |
| Felodipine SCHEMBL27770064 | 0.99 | CYP2C9 (0.98) | CYP2C9CYP3A4HIF1AKDM4EMEN1 | |
| Felodipine SCHEMBL27608150 | 0.99 | CYP2C9 (0.98) | CYP2C9CYP3A4HIF1AKDM4EMEN1 | |
| Felodipine SCHEMBL28260282 | 0.98 | CYP2C9 (0.95) | CYP2C9CYP3A4HIF1AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117442578-A | Felodipine sustained release tablet and preparation method thereof | 浙江京新药业股份有限公司 | 2024-01-26 | — | — | CN | disclosed |
| CN-220125637-U | Filter for producing felodipine | 常州瑞明药业有限公司 | 2023-12-05 | — | — | CN | disclosed |
| CN-114569730-A | Felodipine transdermal drug delivery agent combination, felodipine transdermal drug delivery preparation and transdermal delivery device | 鑫稳生物医药科技(嘉善)有限公司 | 2022-06-03 | — | — | CN | disclosed |