Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SNR3C2
The experimentally established mechanism targets of (R)-Felodipine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C known ✓ | Q13936 | 2/20 | 0.61 |
| ▸ | CACNA1F known ✓ | O60840 | 1/20 | 0.58 |
| ▸ | CACNA1D known ✓ | Q01668 | 1/20 | 0.58 |
| ▸ | CACNA1S known ✓ | Q13698 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 5/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 4/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 3/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 3/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 3/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (R)-Felodipine SCHEMBL29617765 | 1.00 | CYP2C9 (1.00) | CYP2C9CYP3A4HIF1AKDM4EMEN1 | |
| Felodipine SCHEMBL13460298 | 1.00 | CYP2C9 (1.00) | CYP2C9CYP3A4HIF1AKDM4EMEN1 | |
| Felodipine SCHEMBL920025 | 1.00 | CYP2C9 (1.00) | CYP2C9CYP3A4HIF1AKDM4EMEN1 | |
| (S)-Felodipine SCHEMBL26399 | 1.00 | CYP2C9 (1.00) | CYP2C9CYP3A4HIF1AKDM4EMEN1 | |
| Felodipine SCHEMBL26398 | 1.00 | CYP2C9 (1.00) | CYP2C9CYP3A4HIF1AKDM4EMEN1 | |
| (S)-Felodipine SCHEMBL29908048 | 1.00 | CYP2C9 (1.00) | CYP2C9CYP3A4HIF1AKDM4EMEN1 | |
| Felodipine SCHEMBL29049073 | 0.99 | CYP2C9 (0.98) | CYP2C9CYP3A4HIF1AKDM4EMEN1 | |
| Felodipine SCHEMBL27770064 | 0.99 | CYP2C9 (0.98) | CYP2C9CYP3A4HIF1AKDM4EMEN1 | |
| Felodipine SCHEMBL27608150 | 0.99 | CYP2C9 (0.98) | CYP2C9CYP3A4HIF1AKDM4EMEN1 | |
| Felodipine SCHEMBL28260282 | 0.98 | CYP2C9 (0.95) | CYP2C9CYP3A4HIF1AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4273 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4691556-A2 | HUMANIZED ANTI-ACTH ANTIBODIES AND USE THEREOF | H. Lundbeck A/S (DK) | 2026-02-11 | — | — | EP | claimed |
| WO-2025050228-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A PEPTIDE OR A COMBINATION OF PEPTIDES AGONISTIC TO THE MAS, AT1 AND AT2 RECEPTORS | PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE (CL) | 2025-03-13 | — | — | WO | claimed |
| US-20250032503-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | HOTH THERAPEUTICS, INC. | 2025-01-30 | — | — | US | claimed |
| US-20240390364-A1 | Novel Pyridine Compositions and their use in methods for preventing or treating diseases, disorders and conditions | REID CHRISTOPHER BRIAN (US) | 2024-11-28 | — | — | US | claimed |
| CN-117737043-A | Carboxypeptidase A mutant with improved thermostability and activity | 中国农业大学 | 2024-03-22 | — | — | CN | claimed |
| CN-117703889-A | Movable hydraulic circulation cleaning and oil supplementing system | 建龙黑龙江新材料科技有限公司 | 2024-03-15 | — | — | CN | claimed |
| EP-4297868-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | Hoth Therapeutics, Inc. (US) | 2024-01-03 | — | — | EP | claimed |
| CN-116532522-A | Data acquisition device for turnout straightening equipment | 燕山大学 | 2023-08-04 | — | — | CN | claimed |
| US-20230174641-A1 | ANTI-ACTH ANTIBODIES AND USE THEREOF | H LUNDBECK AS (DK) | 2023-06-08 | — | — | US | claimed |
| EP-4057833-A1 | BEVERAGE WITH COLLAGEN AND ADDITIONAL ADDITIVES | Kamcharov, Alexander Evgenievich (RU) | 2022-09-21 | — | — | EP | claimed |
| CN-1403577-A | Fusion protein of type IV collagenase resistant single chain antibody and Lidamycin agon protein | INST MEDICINAL BIOTECHNOLOGY (CN) | 2003-03-19 | — | — | CN | claimed |
| CN-1392975-A | Information recorded medium, information display, information providing device, and information providing system | SONY CORP (JP) | 2003-01-22 | — | — | CN | claimed |
| WO-2002045493-A2 | TRANSGENIC MICE CONTAINING PHOSPHATASE TARGET GENE DISRUPTIONS | DELTAGEN, INC. (US) | 2002-06-13 | — | — | WO | claimed |
| US-20020049155-A1 | Cobalamin compounds useful as cardiovascular agents and as imaging agents | HOGENKAMP HENRICUS P C (US) | 2002-04-25 | — | — | US | claimed |
| US-20020042405-A1 | Epoxy-steroidal aldosterone antagonist and calcium channel blocker combination therapy for treatment of congestive heart failure | SCHUH JOSEPH R (US) | 2002-04-11 | — | — | US | claimed |
| WO-2002009761-A2 | EPOXY-STEROIDAL ALDOSTERONE ANTAGONIST AND CALCIUM CHANNEL BLOCKER COMBINATION THERAPY FOR TREATMENT OF CONGESTIVE HEART FAILURE | PHARMACIA CORPORATION (US) | 2002-02-07 | — | — | WO | claimed |
| WO-2001092283-A2 | COBALAMIN COMPOUNDS USEFUL AS CARDIOVASCULAR AGENTS AND AS IMAGING AGENTS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2001-12-06 | — | — | WO | claimed |
| EP-0874627-A1 | TREATMENT OF URINARY INCONTINENCE WITH NITRIC OXIDE SYNTHASE SUBSTRATES AND/OR NITRIC OXIDE DONORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-11-04 | — | — | EP | claimed |
| WO-1997025984-A1 | TREATMENT OF URINARY INCONTINENCE WITH NITRIC OXIDE SYNTHASE SUBSTRATES AND/OR NITRIC OXIDE DONORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-07-24 | — | — | WO | claimed |
| WO-1992003617-A1 | ROTARY BALLAST WAGON | KERSHAW MANUFACTURING COMPANY, INC. (US) | 1992-03-05 | — | — | WO | claimed |