Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.63 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.63 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.63 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 8/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13229205 | 1.00 | CHRNB2 (0.63) | CHRNB2CHRNA4CHRNB4CHRNA3MAPT | |
| SCHEMBL4875099 | 1.00 | CHRNB2 (0.63) | CHRNB2CHRNA4CHRNB4CHRNA3MAPT | |
| SCHEMBL2793032 | 1.00 | CHRNB2 (0.63) | CHRNB2CHRNA4CHRNB4CHRNA3MAPT | |
| SCHEMBL13202791 | 0.93 | MAPT (0.68) | CHRNB2CHRNA4CHRNB4CHRNA3MAPT | |
| SCHEMBL17054802 | 0.92 | MAPT (0.68) | CHRNB2CHRNA4CHRNB4CHRNA3MAPT | |
| SCHEMBL161270 | 0.90 | MAPT (0.69) | CHRNB2CHRNA4CHRNB4CHRNA3MAPT | |
| SCHEMBL29742107 | 0.90 | MAPT (0.69) | CHRNB2CHRNA4CHRNB4CHRNA3MAPT | |
| SCHEMBL23103819 | 0.88 | MAPT (0.70) | CHRNB2CHRNA4CHRNB4CHRNA3MAPT | |
| SCHEMBL23103843 | 0.84 | CHRNB2 (0.58) | CHRNB2CHRNA4CHRNB4CHRNA3MAPT | |
| SCHEMBL23104350 | 0.84 | CHRNB2 (0.58) | CHRNB2CHRNA4CHRNB4CHRNA3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114641476-B | Preparation and application of protein receptor kinase inhibitors | 上海轶诺药业有限公司 | 2023-05-02 | — | — | CN | disclosed |
| CN-114641476-A | Preparation and application of protein receptor kinase inhibitor | 上海轶诺药业有限公司 | 2022-06-17 | — | — | CN | disclosed |