Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1506640 | 1.00 | KDM4E (0.42) | KDM4EALDH1A1NPSR1HPGDMAPT | |
| SCHEMBL28308270 | 0.84 | KDM4E (0.48) | KDM4EALDH1A1NPSR1HPGDMAPT | |
| SCHEMBL3519553 | 0.75 | GRIN2D (0.40) | KDM4EALDH1A1MAPTL3MBTL1TSHR | |
| SCHEMBL21763267 | 0.75 | TTR (0.42) | TSHR | |
| SCHEMBL29618371 | 0.74 | ALDH1A1 (0.43) | KDM4EALDH1A1NPSR1HPGDMAPT | |
| SCHEMBL4974071 | 0.74 | ALDH1A1 (0.43) | KDM4EALDH1A1NPSR1HPGDMAPT | |
| SCHEMBL19931603 | 0.74 | KDM4E (0.46) | KDM4EALDH1A1NPSR1HPGDMAPT | |
| SCHEMBL1506500 | 0.74 | ALDH1A1 (0.43) | KDM4EALDH1A1NPSR1HPGDMAPT | |
| SCHEMBL21212728 | 0.73 | TTR (0.40) | TSHR | |
| SCHEMBL24517017 | 0.71 | PRKCI (0.34) | KDM4EALDH1A1NPSR1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114591293-A | Fused ring compound as Nav1.8 inhibitor and application thereof | 成都康弘药业集团股份有限公司 | 2022-06-07 | — | — | CN | disclosed |