Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KHK | P50053 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28758443 | 1.00 | SMN1; SMN2 (0.53) | SMN1; SMN2KDM4EGAAPKMPOLB | |
| SCHEMBL24517473 | 0.80 | KDM4E (0.40) | SMN1; SMN2KDM4EGAAPKMKHK | |
| SCHEMBL29618324 | 0.80 | KDM4E (0.40) | SMN1; SMN2KDM4EGAAPKMKHK | |
| SCHEMBL24517534 | 0.80 | KDM4E (0.36) | SMN1; SMN2KDM4EGAAPKMPOLB | |
| SCHEMBL22089493 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2KDM4EGAAPKMPOLB | |
| SCHEMBL30711985 | 0.75 | SMN1; SMN2 (0.64) | SMN1; SMN2KDM4EGAAPKMPOLB | |
| SCHEMBL845573 | 0.75 | SMN1; SMN2 (0.64) | SMN1; SMN2KDM4EGAAPKMPOLB | |
| SCHEMBL16372681 | 0.72 | NPC1 (0.58) | SMN1; SMN2KDM4EGAAPKMPOLB | |
| SCHEMBL5624979 | 0.69 | SMN1; SMN2 (1.00) | SMN1; SMN2KDM4EGAAALDH1A1MAPK1 | |
| SCHEMBL16019318 | 0.69 | SMN1; SMN2 (0.93) | SMN1; SMN2KDM4EGAAPKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022121805-A1 | FUSED RING COMPOUND AS NAV1.8 INHIBITOR AND USE THEREOF | 成都康弘药业集团股份有限公司 | 2022-06-16 | — | — | WO | disclosed |
| CN-114591293-A | Fused ring compound as Nav1.8 inhibitor and application thereof | 成都康弘药业集团股份有限公司 | 2022-06-07 | — | — | CN | disclosed |