Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31677972 | 0.88 | HTR2A (0.42) | MAPTSMN1; SMN2HTR2APDE5APOLB | |
| SCHEMBL29619091 | 0.87 | GABRA5 (0.46) | GABRA5MAPTLMNASMN1; SMN2HTR2A | |
| SCHEMBL29619012 | 0.86 | GABRA5 (0.41) | GABRA5MAPTLMNASMN1; SMN2HTR2A | |
| SCHEMBL29619109 | 0.86 | MAPT (0.44) | GABRA5MAPTLMNASMN1; SMN2HTR2A | |
| SCHEMBL29619040 | 0.83 | HTR2A (0.46) | GABRA5MAPTLMNASMN1; SMN2HTR2A | |
| SCHEMBL29619009 | 0.82 | GABRA5 (0.41) | GABRA5MAPTLMNASMN1; SMN2HTR2A | |
| SCHEMBL29619176 | 0.82 | PDE5A (0.41) | GABRA5MAPTLMNASMN1; SMN2HTR2A | |
| SCHEMBL29619051 | 0.82 | HTR2A (0.51) | HTR2A | |
| SCHEMBL29619101 | 0.82 | HTR2A (0.49) | HTR2ABRD4BRD2BRD3 | |
| SCHEMBL24398567 | 0.81 | POLB (0.52) | MAPTLMNASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4236942-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022093850-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |