Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 2/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2961952 | 1.00 | MEN1 (0.49) | MEN1KMT2AL3MBTL1MAPK10MAPK9 | |
| SCHEMBL2970508 | 0.94 | MEN1 (0.50) | MEN1KMT2AL3MBTL1MAPK10MAPK9 | |
| SCHEMBL2970511 | 0.94 | MEN1 (0.50) | MEN1KMT2AL3MBTL1MAPK10MAPK9 | |
| SCHEMBL2962113 | 0.93 | MEN1 (0.54) | MEN1KMT2AL3MBTL1MAPK10MAPK9 | |
| SCHEMBL2962111 | 0.93 | MEN1 (0.54) | MEN1KMT2AL3MBTL1MAPK10MAPK9 | |
| SCHEMBL2965623 | 0.93 | MEN1 (0.49) | MEN1KMT2AL3MBTL1MAPK10MAPK9 | |
| SCHEMBL2965625 | 0.93 | MEN1 (0.49) | MEN1KMT2AL3MBTL1MAPK10MAPK9 | |
| SCHEMBL2893600 | 0.90 | MEN1 (0.48) | MEN1KMT2AL3MBTL1MAPK10STAT3 | |
| SCHEMBL3348316 | 0.90 | L3MBTL1 (0.49) | MEN1KMT2AL3MBTL1STAT3GRM1 | |
| SCHEMBL3348320 | 0.90 | L3MBTL1 (0.49) | MEN1KMT2AL3MBTL1STAT3GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7763728-B2 | Tetrahydropyridothiophenes | 4SC AG (DE) | 2010-07-27 | — | — | US | claimed |
| US-20090257977-A1 | NOVEL TETRAHYDROPYRIDOTHIOPHENES | PEKARI KLAUS | 2009-10-15 | — | — | US | claimed |
| US-20080260749-A1 | Novel Tetrahydropyridothiophenes | NYCOMED GMBH (DE) | 2008-10-23 | — | — | US | claimed |
| EP-1893618-A2 | TETRAHYDROPYRIDOTHIOPHENES FOR USE IN THE TREATMENT OF CANCER | Nycomed GmbH (DE) | 2008-03-05 | — | — | EP | claimed |
| WO-2006125815-A2 | TETRAHYDROPYRIDOTHIOPHENES FOR USE IN THE TREATMENT OF CANCER | NYCOMED GMBH (DE) | 2006-11-30 | — | — | WO | claimed |
| CN-114096525-A | Biaryl compounds, pharmaceutical compositions containing them, processes for their preparation and their use | 四川科伦博泰生物医药股份有限公司 | 2022-02-25 | — | — | CN | disclosed |
| CN-114096533-A | Tricyclic compound, pharmaceutical composition containing same, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2022-02-25 | — | — | CN | disclosed |
| CN-110678500-A | Photo-or thermosetting method and curable resin composition | 富士胶片和光纯药株式会社 | 2020-01-10 | — | — | CN | disclosed |
| US-7771919-B2 | High refractive index fluids for immersion lithography | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-08-10 | — | — | US | disclosed |
| US-7763728-B2 | Tetrahydropyridothiophenes | 4SC AG (DE) | 2010-07-27 | — | — | US | disclosed |
| US-7763728-B2 | Tetrahydropyridothiophenes | 4SC AG (DE) | 2010-07-27 | — | — | US | disclosed |
| US-7763728-B2 | Tetrahydropyridothiophenes | 4SC AG (DE) | 2010-07-27 | — | — | US | disclosed |
| US-20080061248-A1 | High Refractive Index Fluids for Immersion Lithography | E. I. DU PONT DE NEMOURS AND COMPANY | 2008-03-13 | — | — | US | disclosed |
| US-20080063990-A1 | High Refractive Index Fluids for Immersion Lithography | HONEYWELL INTERNATIONAL, INC. (US) | 2008-03-13 | — | — | US | disclosed |
| EP-1893618-A2 | TETRAHYDROPYRIDOTHIOPHENES FOR USE IN THE TREATMENT OF CANCER | Nycomed GmbH (DE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006125815-A2 | TETRAHYDROPYRIDOTHIOPHENES FOR USE IN THE TREATMENT OF CANCER | NYCOMED GMBH (DE) | 2006-11-30 | — | — | WO | disclosed |
| US-20060122164-A1 | Carboxylic acid esters of pharmaceutical compounds | ASCHER GERD | 2006-06-08 | — | — | US | disclosed |
| EP-1590354-A2 | CARBOXYLIC ACID ESTERS OF PHARMACEUTICAL COMPOUNDS | Sandoz AG (CH) | 2005-11-02 | — | — | EP | disclosed |
| WO-2004067536-A2 | CARBOXYLIC ACID ESTERS TO IMPROVE BIOAVAILABILITY OF PHARMACEUTICAL COMPOUNDS | SANDOZ AG (CH) | 2004-08-12 | — | — | WO | disclosed |
| US-5241017-A | THIONYL PHOSPHAZENE POLYMERS | BAYER AKTIENGESELLSCHAFT (DE) | 1993-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090257977-A1 | NOVEL TETRAHYDROPYRIDOTHIOPHENES | BAX, BCL2, CCAR2 | MEN1 4735/4885KMT2A 2418/4885L3MBTL1 2312/4885 |
| US-20080260749-A1 | Novel Tetrahydropyridothiophenes | BAX, BCL2, CCAR2 | MEN1 4691/4885KMT2A 2644/4885L3MBTL1 2416/4885 |
| US-20060122164-A1 | Carboxylic acid esters of pharmaceutical compounds | MCCC2, HCAR2, CA7 | MEN1 2198/4885KMT2A 2357/4885L3MBTL1 4829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.