Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 3/20 | 0.52 |
| ▸ | SMARCA4 | P51532 | 3/20 | 0.52 |
| ▸ | PBRM1 | Q86U86 | 3/20 | 0.52 |
| ▸ | CCNK | O75909 | 1/20 | 0.42 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 3/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 4/20 | 0.37 |
| ▸ | HPGDS | O60760 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | TERT | O14746 | 1/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.37 |
| ▸ | POLR1A | O95602 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24461312 | 1.00 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1CCNKCDK12 | |
| SCHEMBL24461501 | 0.91 | SMARCA2 (0.42) | SMARCA2SMARCA4PBRM1CCNKCDK12 | |
| SCHEMBL24461358 | 0.87 | PBRM1 (0.38) | SMARCA2SMARCA4PBRM1 | |
| SCHEMBL31505531 | 0.86 | CCNT1 (0.41) | SMARCA2SMARCA4PBRM1CCNKCDK12 | |
| SCHEMBL24461456 | 0.86 | PBRM1 (0.46) | SMARCA2SMARCA4PBRM1CCNT1CDK9 | |
| SCHEMBL30552692 | 0.84 | PBRM1 (0.39) | SMARCA2SMARCA4PBRM1 | |
| SCHEMBL26654036 | 0.84 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1CCNKCDK12 | |
| SCHEMBL30658056 | 0.84 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1CCNKCDK12 | |
| SCHEMBL24461240 | 0.83 | PBRM1 (0.40) | SMARCA2SMARCA4PBRM1 | |
| SCHEMBL24461343 | 0.83 | PBRM1 (0.38) | SMARCA2SMARCA4PBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109426-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2022-05-27 | — | — | WO | disclosed |